phenyl di(p-methylanilido)phosphate | 18995-04-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl di(p-methylanilido)phosphate
• 英文别名: phenyl [N,N'-(p-tolyl)]phosphorodiamidate；N,N'-di-p-tolyl-diamidophosphoric acid phenyl ester；N,N'-Di-p-tolyl-diamidophosphorsaeure-phenylester；Phosphorsaeure-phenylester-di-p-toluidid；4-methyl-N-[(4-methylanilino)-phenoxyphosphoryl]aniline
• CAS: 18995-04-5
• 化学式: C₂₀H₂₁N₂O₂P
• 分子量: 352.373
• InChiKey: RHQBGWSPPAKUGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  phenyl di(p-methylanilido)phosphate 生成 N,N'-di-p-tolyl-diamidophosphoric acid
  参考文献：
  名称：

  MOLLIN, J.;LAZNICKA, J.;KASPAREK, F., COLLECT. CZECH. CHEM. COMMUN., 1983, 48, N 1, 232-242

  摘要：

  DOI：
• 作为产物：
  描述：

  乙烷,三氯氟- 、 二氯磷酸苯酯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以4%的产率得到phenyl di(p-methylanilido)phosphate
  参考文献：
  名称：

  低聚磷酰胺的分步合成

  摘要：

  Ex(PN)ding 链。盐消除和锂化策略用于逐步合成具有 P-N 键的低聚物，由于它们缺乏抗微生物活性，因此具有作为环境友好型阻燃剂的潜力。

  DOI：

  10.1002/ejoc.202101062

文献信息

• Mollin, Jiri; Laznicka, Jiri; Kasparek, Frantisek, Collection of Czechoslovak Chemical Communications, 1983, vol. 48, # 1, p. 232 - 242
  作者：Mollin, Jiri、Laznicka, Jiri、Kasparek, Frantisek

  DOI：——

  日期：——
• Nasogastric Tube Feeding in Children with Cancer: The Effect of Two Different Formulas on Weight, Body Composition, and Serum Protein Concentrations
  作者：Eline den Broeder、Robert J. J. Lippens、Martin A. van 't Hof、Jules J. M. Tolboom、Robert C. A. Sengers、Anneke M. J. van den Berg、Nicole B. M. van Houdt、Zandrie Hofman、Wija A. van Staveren

  DOI：10.1177/0148607100024006351

  日期：2000.11

  Background: Treatment of cancer cachexia partly involves the administration of adequate amounts of energy. The aim of this study was to assess the tolerance and efficacy of two equal volumes of tube feeding, one with a standard (1 kcal/mL) and one with a high energy density (1.5 kcal/mL), during the intensive phase of treatment. Methods: Nutritional status was assessed weekly, in 27 children with a solid tumor, by measuring weight, height, midupper arm circumference, biceps and triceps skinfold, and serum proteins. Tolerance was assessed by recording the occurrence of vomiting and by expressing the administered volume as a percentage of the required volume. Results: Both formulas were equally well tolerated, leading to a significantly higher energy intake in the energy‐enriched formula group. In both formula groups, all anthropometric variables increased significantly (range of mean increase, 5.2% to 25.5%; p <.05) during the first 4 weeks of intervention. Between 4 and 10 weeks, variables continued to increase significantly in the energy‐enriched group, resulting in adequate repletion, in contrast to the standard formula group. The concentration of serum proteins, low at initiation of tube feeding, returned to the normal range within 2 to 4 weeks with no significant differences between the two groups. Conclusions: The energy‐enriched formula was more effective in improving the nutritional status of children with cancer during the intensive phase of treatment than the standard formula. Intensive, protocolized administration of an energy‐enriched formula should therefore be initiated as soon as one of the criteria for initiation of tube feeding is met. (Journal of Parenteral and Enteral Nutrition 24:351–360, 2000)
• MULLIEZ M., PHOSPH. AND SULFUR, 1980, 8, NO 1, 27-35
  作者：MULLIEZ M.

  DOI：——

  日期：——
• ——
  作者：LOCK K. -H.、 MARX J.、 WEISE A.、 BOETTCHER H.

  DOI：——

  日期：——
• The Step‐Wise Synthesis of Oligomeric Phosphoramidates
  作者：Shailja Data、Jeffery Leung Wai、Saawan Kumar、Alan J. Cameron、Manon Trehet、Emeka J. Itumoh、Joey Feld、Tilo Söhnel、Erin M. Leitao

  DOI：10.1002/ejoc.202101062

  日期：2021.10.26

  Ex(P−N)ding the chain. Salt elimination and lithiation strategies were employed in the step-wise synthesis of oligomers with P−N linkages having potential as environment friendly flame retardants due to their lack of anti-microbial activity.

  Ex(PN)ding 链。盐消除和锂化策略用于逐步合成具有 P-N 键的低聚物，由于它们缺乏抗微生物活性，因此具有作为环境友好型阻燃剂的潜力。