2-(3,4-dimethoxyphenyl)-3-fluoro-N,6-diphenylpyridin-4-amine | 1240409-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(3,4-dimethoxyphenyl)-3-fluoro-N,6-diphenylpyridin-4-amine
• CAS: 1240409-61-3
• 化学式: C₂₅H₂₁FN₂O₂
• 分子量: 400.452
• InChiKey: HYTQTSUXOVVMNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  43.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,N-(1,1,1-trifluoro-4-phenylbut-3-yn-2-ylidene)aniline 、 3,4-二甲氧基苄胺 在 caesium carbonate 作用下， 以 四氢呋喃 为溶剂， 以93%的产率得到2-(3,4-dimethoxyphenyl)-3-fluoro-N,6-diphenylpyridin-4-amine
  参考文献：
  名称：

  A New Strategy for the Synthesis of Poly-Substituted 3-H, 3-Fluoro, or 3-Trifluoromethyl Pyridines via the Tandem C−F Bond Cleavage Protocol

  摘要：

  A new strategy for the synthesis of poly-substituted 3-H, 3-F, and 3-trifluoromethyl pyridines based on C-F bond breaking of the anionically activated fluoroalkyl group is described. A series of 2,6-disubstituted 4-amino pyridines were prepared through this domino process in high yields under noble metal-free conditions, making this method a supplement to pyridine synthesis.

  DOI：

  10.1021/ol101859p

文献信息

• A New Strategy for the Synthesis of Poly-Substituted 3-H, 3-Fluoro, or 3-Trifluoromethyl Pyridines via the Tandem C−F Bond Cleavage Protocol
  作者：Zixian Chen、Jiangtao Zhu、Haibo Xie、Shan Li、Yongming Wu、Yuefa Gong

  DOI：10.1021/ol101859p

  日期：2010.10.1

  A new strategy for the synthesis of poly-substituted 3-H, 3-F, and 3-trifluoromethyl pyridines based on C-F bond breaking of the anionically activated fluoroalkyl group is described. A series of 2,6-disubstituted 4-amino pyridines were prepared through this domino process in high yields under noble metal-free conditions, making this method a supplement to pyridine synthesis.