3-(N-乙酰胺基)-5-(N-癸基-N-甲胺基)苄醇 | 103955-90-4

• 物质功能分类: 分析化学 - 标准品 - 法医和兽医标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(N-乙酰胺基)-5-(N-癸基-N-甲胺基)苄醇
• 英文名称: 3-(N-Acetylamino)-5-(N-decyl-N-methylamino)benzyl alcohol
• 英文别名: N-[3-[decyl(methyl)amino]-5-(hydroxymethyl)phenyl]acetamide
• CAS: 103955-90-4
• 化学式: C₂₀H₃₄N₂O₂
• 分子量: 334.5
• InChiKey: YGFQCJGXLSFQPL-UHFFFAOYSA-N

物化性质

• 沸点：
  536.6±50.0 °C(Predicted)
• 密度：
  1.035±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• WGK Germany：
  3
• 海关编码：
  2924299090

文献信息

• Anti-inflammatory compositions
  申请人：PROCYON PHARMACEUTICALS, INC.

  公开号：EP0455271A2

  公开（公告）日：1991-11-06

  Compounds having anti-inflammatory and other activities. The compounds are derived from diterpenes, indol alkaloids, polyacetates, diaminobenzyl alcohols, diacylglycerol and bryostatins.

  具有消炎和其他活性的化合物。这些化合物来自二萜、吲哚生物碱、多乙酸酯、二氨基苄醇、二酰甘油和白藜芦醇。
• Use of a modulator of protein phosphorylation in the treatment of amyloidosis associated with Alzheimer's disease
  申请人：THE ROCKEFELLER UNIVERSITY

  公开号：EP0457295A2

  公开（公告）日：1991-11-21

  Disclosed is the use of at lease one kinase modulator or phosphatase modulator being capable of increasing or decreasing the rate of proteolytic processing of proteins found in intracellular neurofibrillary tangles and extracellular amyloid plaques for the preparation of a pharmaceutical composition for the treatment of amyloidosis associated with Alzheimer's disease, wherein said pharmaceutical composition contains said modulator in an amount effectively regulating phosphorylation of said proteins.

  公开了至少一种激酶调节剂或磷酸酶调节剂的用途，它们能够提高或降低细胞内神经纤维缠结和细胞外淀粉样斑块中蛋白质的蛋白水解处理速度，用于制备治疗与阿尔茨海默病相关的淀粉样变性的药物组合物，其中所述药物组合物含有所述调节剂，其用量可有效调节所述蛋白质的磷酸化。
• Protein kinase C activators and their use in decreasing expression of cell antigens
  申请人：The Trustees of Columbia University

  公开号：US20020040062A1

  公开（公告）日：2002-04-04

  A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided for this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.

  本发明提供了一种上调细胞抗原表达而不诱导脱落的组合物，该组合物包含蛋白激酶 C 激活剂。本发明还提供了一种检测和治疗肿瘤细胞的方法，该方法包括将肿瘤细胞与有效量的蛋白激酶 C 激活剂接触，以上调肿瘤细胞抗原的表达，而不诱导抗原脱落，并检测所述抗原的存在，或进一步将所述肿瘤细胞与有效量的针对所述抗原的抗体接触。
• Modifying the permeability of physiological barriers
  申请人：Eisai Co., Limited

  公开号：US20020142943A1

  公开（公告）日：2002-10-03

  The degree of phosphorylation of serine and threonine residues of p100/p120 can affect the permeability of physiological barriers and also cell-cell adhesion properties. By changing physiological levels, various disorders can be treated, including multiple sclerosis, cancer, head injuries, oedema, stroke, inflammation and gastric ulcers. Furthermore, drugs can be allowed to pass across physiological barriers and the barriers can then be closed.

  p100/p120 丝氨酸和苏氨酸残基的磷酸化程度会影响生理屏障的通透性以及细胞间的粘附特性。通过改变生理水平，可以治疗各种疾病，包括多发性硬化症、癌症、头部损伤、水肿、中风、炎症和胃溃疡。此外，还可以让药物穿过生理屏障，然后关闭屏障。
• Identification of compounds which stimulate bone formation using a cell-based screening assay targeting BMP signaling
  申请人：——

  公开号：US20040009511A1

  公开（公告）日：2004-01-15

  Methods and compositions for measuring the effects of molecules which stimulate BMP and Cbfa1 signaling are disclosed, wherein the response elements in the Smad family and Cbfa1 are utilized in an assay system to modulate the production of an assayable product of a reporter construct.

  本发明公开了用于测量刺激 BMP 和 Cbfa1 信号传导的分子的效应的方法和组合物，其中 Smad 家族和 Cbfa1 中的反应元件被用于检测系统，以调节报告构建物的可检测产物的产生。