1-Fluoro-2-(2-butenyl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Fluoro-2-(2-butenyl)benzene
• 英文别名: 1-[(E)-but-2-enyl]-2-fluorobenzene
• 化学式: C₁₀H₁₁F
• 分子量: 150.196
• InChiKey: NCSYIEJSUDRIMY-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  氟苯 、 3-氯-1-丁烯 在 indium 、 4 Angstroem MS 、 calcium carbonate 作用下， 以 xylene 为溶剂， 反应 2.5h， 生成 1-(but-2-en-1-yl)-4-fluorobenzene 、 1-Fluoro-2-(2-butenyl)benzene
  参考文献：
  名称：

  铟金属催化的芳族化合物与烯丙基氯化物的新的直接烯丙基化

  摘要：

  开发了一种在Å分子筛存在下使用催化量的铟与芳基氯化物进行芳族化合物直接烯丙基化反应的新方法。

  DOI：

  10.1016/s0040-4039(98)02707-5

文献信息

• PHENYLPROPIONIC ACID DERIVATIVE AND USE THEREOF
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP2272832A1

  公开（公告）日：2011-01-12

  A compound represented by the following general formula (1) or a salt thereof, which has superior inhibitory activity against type 4 PLA2, and thus has prostaglandin and/or leucotriene production suppressing action [X represents a halogen atom, an alkyl group which may be substituted, or the like, Y represents hydrogen atom or an alkyl group which may be substituted, and Z represents hydrogen atom or an alkyl group which may be substituted].

  由以下通式（1）代表的化合物或其盐，对 4 型 PLA2 具有优异的抑制活性，因此具有抑制前列腺素和/或白三烯产生的作用[X 代表卤原子、可被取代的烷基或类似物，Y 代表氢原子或可被取代的烷基，Z 代表氢原子或可被取代的烷基]。
• Phenyl alkyl carbamate derivative compound and pharmaceutical composition containing the same
  申请人：Bio-Pharm Solutions Co., Ltd.

  公开号：EP2797881A1

  公开（公告）日：2014-11-05
• PHENYL ALKYL CARBAMATE COMPOUNDS FOR USE IN PREVENTING OR TREATING EPILEPSY OR EPILEPSY-RELATED SYNDROME
  申请人：Bio-Pharm Solutions Co., Ltd.

  公开号：EP2968211A1

  公开（公告）日：2016-01-20
• [EN] Phenyl alkyl carbamate derivative compound and pharmaceutical composition containing the same<br/>[FR] COMPOSÉ DE DÉRIVÉS DE CARBAMATE D'ALKYLE PHÉNYLE ET COMPOSITION PHARMACEUTIQUE EN CONTENANT
  申请人：BIO PHARM SOLUTIONS CO LTD

  公开号：WO2013100566A1

  公开（公告）日：2013-07-04

  A phenyl alkyl carbamate derivative compound and a pharmaceutical composition containing the compound are provided. More specifically, the phenyl alkyl carbamate derivative compound and a pharmaceutically acceptable salt thereof, a composition for muscle relaxation containing the compounds and/or pharmaceutically acceptable salt thereof as an active ingredient, and a use of the phenyl alkyl carbamate derivative compound and/or a pharmaceutically acceptable salt thereof for muscle relaxation, are provided.
• [EN] PHENYL ALKYL CARBAMATE COMPOUNDS FOR USE IN PREVENTING OR TREATING EPILEPSY OR EPILEPSY-RELATED SYNDROME<br/>[FR] COMPOSÉS DE PHÉNYLALKYLCARBAMATE POUR UTILISATION DANS LA PRÉVENTION OU LE TRAITEMENT DE L'ÉPILEPSIE OU D'UN SYNDROME LIÉ À L'ÉPILEPSIE
  申请人：BIO PHARM SOLUTIONS CO LTD

  公开号：WO2014142519A1

  公开（公告）日：2014-09-18

  The present invention provides a pharmaceutical composition for preventing and/or treating a epilepsy or epilepsy-related syndrome, for example an intractable epilepsy or its related syndrome such as drug-resistant epilepsy, comprising the phenyl alkyl carbamate compound as an active ingredient, and a use of the phenyl alkyl carbamate compound for preventing and/or treating epilepsy or epilepsy-related syndrome.