(2S,4S,5S,6S)-7-[tert-butyl(dimethyl)silyl]oxy-5-hydroxy-1-[(4-methoxyphenyl)methoxy]-2,4,6-trimethylheptan-3-one | 1186618-97-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,4S,5S,6S)-7-[tert-butyl(dimethyl)silyl]oxy-5-hydroxy-1-[(4-methoxyphenyl)methoxy]-2,4,6-trimethylheptan-3-one
• CAS: 1186618-97-2
• 化学式: C₂₄H₄₂O₅Si
• 分子量: 438.68
• InChiKey: DJKIJYSMXUJVSO-XWQURZDVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2S,4S,5S,6S)-7-[tert-butyl(dimethyl)silyl]oxy-5-hydroxy-1-[(4-methoxyphenyl)methoxy]-2,4,6-trimethylheptan-3-one 在 tetramethylammonium triacetoxyborohydride 作用下， 以 溶剂黄146 、 乙腈 为溶剂， 生成 、 (2S,3S,4R,5S,6S)-1-[tert-butyl(dimethyl)silyl]oxy-7-[(4-methoxyphenyl)methoxy]-2,4,6-trimethylheptane-3,5-diol
  参考文献：
  名称：

  Synthetic studies on reidispongiolide A, an actin-depolymerizing marine macrolide: synthesis of C11–C22 and C23–C35 segments

  摘要：

  The C11-C22 and C23-C35 segments 2 and 3 of reidispongiolide A (1), an actin-depolymerizing marine macrolide, were synthesized enantioselectively in 12 steps from (R)-glycidyl trityl ether and in 12 steps from chiral ketone 15, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.075
• 作为产物：
  描述：

  (2S)-3-(tert-butyl-dimethyl-silyloxy)-2-methyl-propanal 、 (S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one 在 氯代二环己基硼烷 、 三乙胺 作用下， 以 乙醚 为溶剂， 生成 (2S,4S,5S,6S)-7-[tert-butyl(dimethyl)silyl]oxy-5-hydroxy-1-[(4-methoxyphenyl)methoxy]-2,4,6-trimethylheptan-3-one
  参考文献：
  名称：

  Synthetic studies on reidispongiolide A, an actin-depolymerizing marine macrolide: synthesis of C11–C22 and C23–C35 segments

  摘要：

  The C11-C22 and C23-C35 segments 2 and 3 of reidispongiolide A (1), an actin-depolymerizing marine macrolide, were synthesized enantioselectively in 12 steps from (R)-glycidyl trityl ether and in 12 steps from chiral ketone 15, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.075