(4-nitrophenyl) N-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propyl]carbamate | 391624-41-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (4-nitrophenyl) N-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propyl]carbamate
• CAS: 391624-41-2
• 化学式: C₃₅H₃₅N₃O₇
• 分子量: 609.679
• InChiKey: XPVRPIRTJIABSB-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  45
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (S)-2-[(4-Nitro-phenoxycarbonylamino)-methyl]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 、 [(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methyl-pentyl]-carbamic acid 4-nitro-phenyl ester 、 (4-nitrophenyl) N-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propyl]carbamate 、 [5-(9H-fluoren-9-ylmethoxycarbonylamino)-6-(4-nitro-phenoxycarbonylamino)-hexyl]-carbamic acid tert-butyl ester 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (S)-2-[3-((S)-1-(4-Hydroxy-benzyl)-2-{3-[(S)-1-((S)-4-isobutyl-2,5-dioxo-imidazolidin-1-ylmethyl)-2-methyl-butyl]-ureido}-ethyl)-ureidomethyl]-pyrrolidine-1-carboxylic acid {(S)-6-amino-2-[3-((S)-2,6-diamino-hexyl)-ureido]-hexyl}-amide 、 (S)-2-[3-((S)-2-{3-[(S)-2-[3-((S)-1-{(S)-6-Amino-2-[3-((S)-2,6-diamino-hexyl)-ureido]-hexylcarbamoyl}-pyrrolidin-2-ylmethyl)-ureido]-3-(4-hydroxy-phenyl)-propyl]-ureido}-3-methyl-pentyl)-ureido]-4-methyl-pentanoic acid
  参考文献：
  名称：

  Solid-Phase Synthesis of Oligourea Peptidomimetics Employing the Fmoc Protection Strategy

  摘要：

  A solid-phase-Fmoc-based-synthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a-j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).

  DOI：

  10.1021/jo010656q
• 作为产物：
  描述：

  9H-fluoren-9-ylmethyl [(1S)-1-(4-tert-butoxybenzyl)-2-hydroxyethyl]carbamate 在 10percent Pd/C 三(2-氯乙基)胺 、 氢气 、 N,N-二异丙基乙胺 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 二氯甲烷 、 氯仿 、 苯 为溶剂， 生成 (4-nitrophenyl) N-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propyl]carbamate
  参考文献：
  名称：

  Solid-Phase Synthesis of Oligourea Peptidomimetics Employing the Fmoc Protection Strategy

  摘要：

  A solid-phase-Fmoc-based-synthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a-j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).

  DOI：

  10.1021/jo010656q

文献信息

• Solid-Phase Synthesis of Oligourea Peptidomimetics Employing the Fmoc Protection Strategy
  作者：Astrid Boeijen、Jeroen van Ameijde、Rob M. J. Liskamp

  DOI：10.1021/jo010656q

  日期：2001.12.1

  A solid-phase-Fmoc-based-synthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a-j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).