L-Cysteine, S-(2,3-dihydroxypropyl)-N-(1-oxohexadecyl)- | 88034-78-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Cysteine, S-(2,3-dihydroxypropyl)-N-(1-oxohexadecyl)-
• 英文别名: (2R)-3-(2,3-dihydroxypropylsulfanyl)-2-(hexadecanoylamino)propanoic acid
• CAS: 88034-78-0
• 化学式: C₂₂H₄₃NO₅S
• 分子量: 433.6
• InChiKey: CGRGRECYWNPZDJ-ANYOKISRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] IMMUNOGENIC AND PROPHYLACTIC COMPOSITIONS, METHODS OF MAKING SAME, AND METHOD FOR TREATING AND PREVENTING TNF-MEDIATED DISEASE AND HIV-1 INFECTION<br/>[FR] COMPOSITIONS IMMUNOGÈNES ET PROPHYLACTIQUES, LEURS PROCÉDÉS DE FABRICATION, ET MÉTHODE DE TRAITEMENT ET DE PRÉVENTION D'UNE MALADIE MÉDIÉE PAR LE TNF ET D'UNE INFECTION PAR LE VIH-1
  申请人：THYMON LLC

  公开号：WO2014116789A1

  公开（公告）日：2014-07-31

  An immunogenic composition comprises a peptide that induces in vivo TNF monomer-specific antibodies that bind an epitope of dissociated monomers of human TNF, the epitope being located wholly or partially within a TNF monomer-monomer interface region. Antibodies induced in vivo by this composition disrupt assembly or prevent re-assembly of the TNF monomers into bioactive trimeric human sTNF. The composition can comprise an additional peptide that induces in vivo TNF monomer- specific antibodies that bind another epitope of dissociated monomers of human TNF. Methods of making these immunogenic compositions are also described. Methods for treating a subject having a disease mediated by human TNF comprise administering a described immunogenic compositions which induces antibodies in a treated subject that disrupt or reduce the in vivo assembly or reassembly of dissociated monomers of TNF into bioactive trimeric human sTNF. These compositions and methods do not affect the structure or bioactivity of tmTNF or increase the treated subject's susceptibility to infection by an intracellular pathogen.