ethyl (2Z)-2-azido-3-(3-thienyl)-2-propenoate | 335030-68-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl (2Z)-2-azido-3-(3-thienyl)-2-propenoate
• 英文别名: ethyl (Z)-2-azido-3-thiophen-3-ylprop-2-enoate
• CAS: 335030-68-7
• 化学式: C9H9N3O2S
• 分子量: 223.25
• InChiKey: YYFNNZKWCYPIDF-YVMONPNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  68.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl (2Z)-2-azido-3-(3-thienyl)-2-propenoate 以87%的产率得到
  参考文献：
  名称：

  ERAS, J.;GALVEZ, C.;GARCIA, F., J. HETEROCYCL. CHEM., 1984, 21, N 1, 215-217

  摘要：

  DOI：
• 作为产物：
  描述：

  叠氮乙酸乙酯 、 3-噻吩甲醛 以50%的产率得到
  参考文献：
  名称：

  ERAS, J.;GALVEZ, C.;GARCIA, F., J. HETEROCYCL. CHEM., 1984, 21, N 1, 215-217

  摘要：

  DOI：

文献信息

• FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE
  申请人：Heffernan L. R. Michele

  公开号：US20080004327A1

  公开（公告）日：2008-01-03

  This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CR 1 and N. X and Y are members independently selected from O, S, CR 2 , N and NH. R 1 , R 2 and R 4 are members independently selected from H and F, provided that at least one member selected from R 1 , R 2 and R 4 is F. R 6 is a member selected from O − X + and OH, wherein X + is a positive ion, which is a member selected from inorganic positive ions and organic positive ions.

  这项发明提供了D-氨基酸氧化酶的新型抑制剂，以及包括该发明中化合物的药物组合物。该发明还提供了用于治疗和预防神经系统疾病，如神经精神病和神经退行性疾病，以及疼痛、共济失调和抽搐的方法。该发明中的化合物具有一般结构：其中A为NH或S。Q是从CR1和N中选择的成员。X和Y分别是从O、S、CR2、N和NH中独立选择的成员。R1、R2和R4是从H和F中独立选择的成员，前提是至少选择R1、R2和R4中的一个成员为F。R6是从O−X+和OH中选择的成员，其中X+是正离子，从无机正离子和有机正离子中选择的成员。
• Fused heterocyclic inhibitors of D-amino acid oxidase
  申请人：Heffernan L. R. Michele

  公开号：US20080058395A1

  公开（公告）日：2008-03-06

  This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein Q is a member selected from O, S, CR 1 and N, X and Y are members independently selected from CR 2 , O, S, N and NR 3 .

  本发明提供了D-氨基酸氧化酶的新型抑制剂，以及包括该发明化合物的制药组合物。同时，还提供了治疗和预防神经系统疾病，如神经精神疾病和神经退行性疾病，以及疼痛、共济失调和惊厥的方法。该发明化合物具有以下一般结构：其中Q是从O、S、CR1和N中选择的成员，X和Y是独立选择自CR2、O、S、N和NR3的成员。
• Fab I Inhibitors
  申请人：Miller William H.

  公开号：US20110190283A1

  公开（公告）日：2011-08-04

  Compounds of the Formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.

  公开了式(I)的化合物，它们是Fab I抑制剂，可用于治疗细菌感染。
• HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS
  申请人：PHARMAKEA, INC.

  公开号：US20160229809A1

  公开（公告）日：2016-08-11

  Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.

  本文描述了自体轴突素抑制剂化合物，制备这些化合物的方法，包括这些化合物的药物组合物和药物，以及在治疗与自体轴突素活性相关的病症、疾病或障碍方面使用这些化合物的方法。
• FLUORESCENT COMPOUND AND LABELING AGENT COMPRISING THE SAME
  申请人：Keio University

  公开号：EP2022794B1

  公开（公告）日：2017-08-23