2-amino-3-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-hydroxymethyl-propionic acid | 879997-67-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-3-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-hydroxymethyl-propionic acid
• 英文别名: 2-amino-2-[(1-benzyl-3,6-dihydro-2H-pyridin-4-yl)methyl]-3-hydroxypropanoic acid
• CAS: 879997-67-8
• 化学式: C₁₆H₂₂N₂O₃
• 分子量: 290.362
• InChiKey: PKZBAYZHUKVPAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  86.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-ylmethyl)-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid benzyl ester 在 水 作用下， 生成 2-amino-3-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-hydroxymethyl-propionic acid
  参考文献：
  名称：

  Compositions for enhancing memory and methods therefor

  摘要：

  提供了用于增强主体记忆的组合物，包括AMPA受体的正调节剂和NMDA受体的正调节剂，其中组合物中的每种调节剂均以次治疗剂量存在，以实现记忆增强效果。提供了在治疗与衰老、与年龄相关的疾病和中枢神经系统疾病相关的认知障碍中使用这种组合物的方法。还提供了将正调节剂功能结合到一个分子中的新融合分子。

  公开号：

  US20060063707A1

文献信息

• PSYCHO-PHARMACEUTICALS
  申请人：University College Dublin National University Of Ireland, Dublin

  公开号：EP2288345B1

  公开（公告）日：2015-06-10
• [EN] COMPOSITIONS FOR ENHANCING MEMORY AND METHODS THEREFOR<br/>[FR] COMPOSITIONS POUR RENFORCER LA MÉMOIRE ET PROCÉDÉS IDOINES
  申请人：LIFELIKE BIOMATIC INC

  公开号：WO2006034196A1

  公开（公告）日：2006-03-30

  Compositions for enhancing memory of a subject comprising a combination of a positive modulator of an AMPA receptor and a positive modulator of an NMDA receptor are provided, wherein each modulator of the combination is present at a subtherapeutic dose for effecting memory enhancement. Methods for using such compositions in the treatment of cognitive impairment associated with aging, age-related diseases, and CNS disorders, for example, are provided. New fusion molecules are also provided that combine the positive modulator functionalities into one molecule.
• [EN] PSYCHO-PHARMACEUTICALS<br/>[FR] PRODUITS PSYCHO-PHARMACEUTIQUES
  申请人：UNIV DUBLIN

  公开号：WO2009128058A1

  公开（公告）日：2009-10-22

  The invention provides a compound for use in the treatment of symptoms associated with psychosis, schizophrenia, a cognitive impairment disorder, a mood disorder, a nervous system disorder and/or a behavioral disorder. The compound has the formula ? and is administered to a subject in need thereof in an effective amount. The compound Meparfynol (3-methylpent-l-yn-3-ol) has been found to be effective.