(2R,3R,4R)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-4-methylpyrrolidine | 872534-48-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,3R,4R)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-4-methylpyrrolidine
• 英文别名: (2R,3R,4R)-4-methyl-3,4-bis(phenylmethoxy)-2-(phenylmethoxymethyl)pyrrolidine
• CAS: 872534-48-0
• 化学式: C₂₇H₃₁NO₃
• 分子量: 417.548
• InChiKey: BYJNCVQTUKWDTB-ZONZVBGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2R,3R,4R)-tert-butyl 3,4-bis(Benzyloxy)-2-(benzyloxymethyl)-4-methylpyrrolidine-1-carboxylate 在 三氟乙酸 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以74%的产率得到(2R,3R,4R)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-4-methylpyrrolidine
  参考文献：
  名称：

  从天然糖和氨基酸合成亚氨基糖（2 R，3 R，4 S）-2-（羟甲基）-4-甲基吡咯烷-3,4-二醇的方法

  摘要：

  从核糖和d-丝氨酸开始，通过两种替代途径制备了亚氨基糖化合物3。由d-丝氨酸（3 R，4 R，5 R）-3,4-二羟基-5-（羟甲基）-3-甲基吡咯烷丁-2-酮以五个步骤制备，总收率为50％，将其进一步转化为（2 R，3 R，4 S）-2-（羟甲基）-4-甲基吡咯烷-3,4-二醇分三步进行，总收率为23％。

  DOI：

  10.1016/j.tetlet.2010.11.068

文献信息

• [EN] AZA NUCLEOSIDES, PREPARATION THEREOF AND USE AS INHIBITORS OF RNA VIRAL POLYMERASES<br/>[FR] AZANUCLEOSIDES, LEUR PREPARATION ET LEUR UTILISATION COMME INHIBITEUR DES ARN POLYMERASES VIRALES
  申请人：BIOCRYST PHARM INC

  公开号：WO2006002231A1

  公开（公告）日：2006-01-05

  Compounds represented by the formula: (I), and pharmaceutically acceptable salts thereof and prodrugs thereof; wherein Rl is H, CH3, C2H5, C3H7 R2 is H, CH3, C2H5, C3H7, CH=CH2, CH2-OH, CH2F, CF3 R'2 is H, OH, NH2, NH-alkyl, F, N3, OCH3, O-C(O)CH(NH2)alkyl R3 is H, CH3, C2H5, C3H7 R'3 is H, OH, NH2, NH-alkyl, F, N3, OCH3, O-C(O)CH(NH2)alkyl R4 is H, CH3, C2H5, C3H7 At least one of R2, R3, or R4 has to be other than H, when X=NH in B R6 is H, CH3, C2H5, -C-CH3 R7 is selected from H, alkyl, alkenyl, aryl, acyloxyalkyl, and pivaloyloxyalkyl, aminoacids, CH2CH2SC(O)alkyl; and B is represented by the following structure: X is independently NR6, O, S, R8 and R9 independently is H, NH2, OH, SH, F, Cl, Br, I, aryl, heterocycle, alkyl, alkene, alkyne, S-alkyl, S-aryl, S(O)-alkyl, SO2-alkyl, SO2NH2, SO2NH-alkyl, SO2NH-aryl, NH-alkyl, NH-aryl, N(alkyl)2, N(aryl)2, O-alkyl, O-aryl, O-heterocycle, NH-(CH2)n-aryl, NH-C(O)-alkyl, NH-C(O)-aryl are useful for inhibiting viral RNA polymerases and treating patients suffering from diseases caused by various RNA viruses.

  由以下公式表示的化合物：(I)，以及其药用盐和前药；其中R1为H，CH3，C2H5，C3H7；R2为H，CH3，C2H5，C3H7，CH=CH2，CH2-OH，CH2F，CF3；R'2为H，OH，NH2，NH-烷基，F，N3，OCH3，O-C(O)CH(NH2)烷基；R3为H，CH3，C2H5，C3H7；R'3为H，OH，NH2，NH-烷基，F，N3，OCH3，O-C(O)CH(NH2)烷基；R4为H，CH3，C2H5，C3H7；当X=NH时，R2，R3或R4中至少有一个不是H；R6为H，CH3，C2H5，-C-CH3；R7从H，烷基，烯基，芳基，酰氧烷基，皮瓦洛氧烷基，氨基酸，CH2CH2SC(O)烷基中选择；B由以下结构表示：X独立地为NR6，O，S；R8和R9独立地为H，NH2，OH，SH，F，Cl，Br，I，芳基，杂环，烷基，烯烃，炔烃，S-烷基，S-芳基，S(O)-烷基，SO2-烷基，SO2NH2，SO2NH-烷基，SO2NH-芳基，NH-烷基，NH-芳基，N(烷基)2，N(芳基)2，O-烷基，O-芳基，O-杂环，NH-(CH2)n-芳基，NH-C(O)-烷基，NH-C(O)-芳基对抑制病毒RNA聚合酶并治疗由各种RNA病毒引起的疾病的患者具有用处。
• AZA nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
  申请人：Babu S. Yarlagadda

  公开号：US20070099942A1

  公开（公告）日：2007-05-03

  Compounds represented by the formula: , and pharmaceutically acceptable salts thereof and prodrugs thereof; wherein R 1 is H, CH 3 , C 2 H 5 , C 3 H 7 R 2 is H, CH 3 , C 2 H 5 , C 3 H 7 , CH═CH 2 , CH 2 —OH, CH 2 F, CF 3 R′ 2 is H, OH, NH 2 , NH-alkyl, F, N 3 , OCH 3 , O—C(O)CH(NH 2 )alkyl R 3 is H, CH 3 , C 2 H 5 , C 3 H 7 R′ 3 is H, OH, NH 2 , NH-alkyl, F, N 3 , OCH 3 , O—C(O)CH(NH 2 )alkyl R 4 is H, CH 3 , C 2 H 5 , C 3 H 7 At least one of R 2 , R 3 , or R 4 has to be other than H, when X═NH in B R 6 is H, CH 3 , C 2 H 5 , R 7 is selected from H, alkyl, alkenyl, aryl, acyloxyalkyl, and pivaloyloxyalkyl, aminoacids, CH 2 CH 2 SC(O)alkyl; and B is represented by the following structure: X is independently NR 6 , O, S, R 8 and R 9 independently is H, NH 2 , OH, SH, F, Cl, Br, I, aryl, heterocycle, alkyl, alkene, alkyne, S-alkyl, S-aryl, S(O)-alkyl, SO 2 -alkyl, SO 2 NH 2 , SO 2 NH-alkyl, SO 2 NH-aryl, NH-alkyl, NH-aryl, N(alkyl) 2 , N(aryl) 2 , O-alkyl, O-aryl, O-heterocycle, NH-(CH 2 ) n -aryl, NH—C(O)-alkyl, NH—C(O)-aryl are useful for inhibiting viral RNA polymerases and treating patients suffering from diseases caused by various RNA viruses.

  该化合物的结构式为：其中R1为H，CH3，C2H5，C3H7；R2为H，CH3，C2H5，C3H7，CH═CH2，CH2—OH，CH2F，CF3；R′2为H，OH，NH2，NH-烷基，F，N3，OCH3，O—C（O）CH（NH2）烷基；R3为H，CH3，C2H5，C3H7；R′3为H，OH，NH2，NH-烷基，F，N3，OCH3，O—C（O）CH（NH2）烷基；R4为H，CH3，C2H5，C3H7。当X═NH时，R2、R3或R4中至少有一个不为H。BR6为H，CH3，C2H5；R7选择自H、烷基、烯烃基、芳香基、酰氧烷基和哌酰氧烷基、氨基酸、CH2CH2SC（O）烷基；B的结构式如下：其中X独立为NR6，O，S；R8和R9独立为H，NH2，OH，SH，F，Cl，Br，I，芳香基，杂环，烷基，烯烃基，炔基，S-烷基，S-芳香基，S（O）-烷基，SO2-烷基，SO2NH2，SO2NH-烷基，SO2NH-芳香基，NH-烷基，NH-芳香基，N（烷基）2，N（芳香基）2，O-烷基，O-芳香基，O-杂环，NH-（CH2）n-芳香基，NH—C（O）-烷基，NH—C（O）-芳香基。这些化合物可用于抑制病毒RNA聚合酶和治疗由各种RNA病毒引起的患者。此外，还包括这些化合物的药物可接受的盐和前药。
• US7560434B2
  申请人：——

  公开号：US7560434B2

  公开（公告）日：2009-07-14
• Synthetic approaches to imino sugar (2R,3R,4S)-2-(hydroxymethyl)-4-methylpyrrolidine-3,4-diol from naturally occurring sugar and amino acid
  作者：Pravin L. Kotian、Ajit Ghosh、Tsu-Hsing Lin、Minwan Wu、V. Satish Kumar、Yarlagadda S. Babu、Pooran Chand

  DOI：10.1016/j.tetlet.2010.11.068

  日期：2011.1

  Imino sugar compound 3 was prepared by two alternative routes starting from ribose and d-serine. From d-serine (3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methylpyrrolidin-2-one was prepared in five steps in 50% overall yield, which was further converted into (2R,3R,4S)-2-(hydroxymethyl)-4-methylpyrrolidine-3,4-diol in three steps in 23% overall yield.

  从核糖和d-丝氨酸开始，通过两种替代途径制备了亚氨基糖化合物3。由d-丝氨酸（3 R，4 R，5 R）-3,4-二羟基-5-（羟甲基）-3-甲基吡咯烷丁-2-酮以五个步骤制备，总收率为50％，将其进一步转化为（2 R，3 R，4 S）-2-（羟甲基）-4-甲基吡咯烷-3,4-二醇分三步进行，总收率为23％。