Tcy-NH2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tcy-NH2
• 英文别名: (2S)-N-[2-[[(2S)-6-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]-1-[(2S)-3-(4-hydroxyphenyl)-2-[[(E)-3-phenylprop-2-enoyl]amino]propanoyl]pyrrolidine-2-carboxamide
• 化学式: C₄₀H₄₉N₇O₇
• 分子量: 739.9
• InChiKey: XKRAKQXQVIGYQC-PHOSSJRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  54
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  226
• 氢给体数：
  7
• 氢受体数：
  8

文献信息

• TREATMENT OF PULMONARY HYPERTENSION USING AN AGENT THAT INHIBITS A TISSUE FACTOR PATHWAY
  申请人：UNIVERSITY OF ROCHESTER

  公开号：EP1799243A2

  公开（公告）日：2007-06-27
• Treatment of Pulmonary Hypertension Using an Agent That Inhibits a Tissue Factor Pathway
  申请人：White R. James

  公开号：US20080267969A1

  公开（公告）日：2008-10-30

  An improved non-human animal model of severe pulmonary arterial hypertension (PAH) and its use for testing of therapeutic agents that can treat symptoms of PAH are disclosed. In addition, the present application relates to the identification of several classes of therapeutic agents that, alone or in combination, can be used to treat or prevent PAH or at least reduce the severity of symptoms associated therewith. Both gene therapy and non-gene therapy approaches are described.
• US8563511B2
  申请人：——

  公开号：US8563511B2

  公开（公告）日：2013-10-22
• [EN] TREATMENT OF PULMONARY HYPERTENSION USING AN AGENT THAT INHIBITS A TISSUE FACTOR PATHWAY<br/>[FR] TRAITEMENT DE L'HYPERTENSION PULMONAIRE AU MOYEN D'UN AGENT INHIBANT UNE VOIE DU FACTEUR TISSULAIRE
  申请人：UNIV ROCHESTER

  公开号：WO2006042017A2

  公开（公告）日：2006-04-20

  An improved non-human animal model of severe pulmonary arterial hypertension (PAH) and its use for testing of therapeutic agents that can treat symptoms of PAH are disclosed. In addition, the present application relates to the identification of several classes of therapeutic agents that, alone or in combination, can be used to treat or prevent PAH or at least reduce the severity of symptoms associated therewith. Both gene therapy and non-gene therapy approaches are described.