3-(四氢呋喃-3-基)丙烷-1-胺 | 684221-29-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 中文名称: 3-(四氢呋喃-3-基)丙烷-1-胺
• 英文名称: 3-(Tetrahydrofuran-3-yl)propan-1-amine
• 英文别名: 3-(oxolan-3-yl)propan-1-amine
• CAS: 684221-29-2
• 化学式: C₇H₁₅NO
• 分子量: 129.2
• InChiKey: NQFUHISZSMKCHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2932190090

文献信息

• Pyrimidine derivatives as IL-8 receptor antagonists
  申请人：——

  公开号：US20040087601A1

  公开（公告）日：2004-05-06

  Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I 1 In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, —O—alkyl or —S-alkyl. A representative example is: 2

  含有嘧啶核的化合物及其用于治疗与不适当的白细胞介素-8受体活性相关的疾病和症状的用途已被披露。这些化合物的结构式为I 1 在这些化合物中，Q最好是未取代或取代的杂环烷基；U通常是氢或氟；V最好是氢、卤素、烷基、—O—烷基或—S-烷基。一个代表性的例子是： 2
• [EN] IMIDAZOLYL PYRIMIDINE DERIVATIVES USEFUL AS IL-8 RECEPTOR MODULATORS<br/>[FR] DERIVES DE D'IMIDAZOLYL PYRIMIDINE UTILISES COMME MODULATEURS DU RECEPTEUR DE IL-8
  申请人：PHARMACOPEIA DRUG DISCOVERY

  公开号：WO2004063192A1

  公开（公告）日：2004-07-29

  The invention relates to compounds of the formula I, wherein R1, R2, R3 and R4 are each independently selected from H, (1-4C)alkyl, (1-4C)alkoxy, trifluoromethyl, trifluoromethoxy, halogen, amino, sulfonamide, cyano, OH and nitro; R5 is H or (1-6C)alkyl; R6 is H, (1-6C)alkyl or (1-6C)alkoxy; R7 is H or (1-6C)alkyl; R8 is (1-6C)alkyl, optionally substituted with (1-6C)alkoxy; R9 is -(CH2)nR10, wherein n is 1, 2 or 3 and R10 is selected from (1-4C)alkoxy, (1-4C)alkylthio, trifluoromethyl, (3-8C)cycloalkyl, phenyl optionally substituted with (1-4C)alkoxy, -NR11R12 and -O(CH2)2NR11R12, wherein one of R11 and R12 is (1-4C)alkoxy, the other being H or (1-4C)alkyl, or R9 is -CH2(2-7C)heterocycloalkyl, provided that when at least one heteroatom in the heterocycloalkyl moiety is nitrogen, the distance between this nitrogen and the nitrogen in 'NHR9' is at least three carbon atoms, or R9 is -(CH2)3(2-7C)heterocycloalkyl or -(CH2)2CHR13R14, wherein R13 and R14 together with the carbon atom to which they are attached, are (2-7C)heterocycloalkyl; and X is O, S or NH; or a pharmaceutically acceptable salt thereof. The compounds of the invention are Il-8 receptor modulators, in particular inhibitors thereof, and can be used for treating or preventing Il-8 receptor mediated disorders, such as atherosclerosis, inflammation, rheumatoid arthritis and related disorders.

  该发明涉及公式I的化合物，其中R1、R2、R3和R4分别独立地选择自H、(1-4C)烷基、(1-4C)烷氧基、三氟甲基、三氟甲氧基、卤素、氨基、磺酰胺基、氰基、羟基和硝基；R5为H或(1-6C)烷基；R6为H、(1-6C)烷基或(1-6C)烷氧基；R7为H或(1-6C)烷基；R8为(1-6C)烷基，可选地取代为(1-6C)烷氧基；R9为-(CH2)nR10，其中n为1、2或3，R10选自(1-4C)烷氧基、(1-4C)烷基硫醚、三氟甲基、(3-8C)环烷基、苯基，可选地取代为(1-4C)烷氧基，-NR11R12和-O(CH2)2NR11R12，其中R11和R12中的一个为(1-4C)烷氧基，另一个为H或(1-4C)烷基，或R9为-CH2(2-7C)杂环烷基，但至少一个杂原子在杂环烷基基团中是氮时，该氮与“NHR9”中的氮之间的距离至少为三个碳原子，或R9为-(CH2)3(2-7C)杂环烷基或-(CH2)2CHR13R14，其中R13和R14与它们连接的碳原子一起，是(2-7C)杂环烷基；X为O、S或NH；或其药学上可接受的盐。该发明的化合物是Il-8受体调节剂，特别是其抑制剂，并可用于治疗或预防Il-8受体介导的疾病，如动脉粥样硬化、炎症、类风湿关节炎及相关疾病。
• US7037916B2
  申请人：——

  公开号：US7037916B2

  公开（公告）日：2006-05-02
• [EN] PYRIMIDINE DERIVATIVES AS IL-8 RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE PYRIMIDINE UTILISES COMME ANTAGONISTES DES RECEPTEURS DE L'IL-8
  申请人：PHARMACOPEIA INC

  公开号：WO2004062609A2

  公开（公告）日：2004-07-29

  Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula (I). In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, -O-alkyl or -S-alkyl. A representative example is formula (X).