6-Heptafluoropropyl-3-hydroxy-3-methyl-2,3-dihydro-pyran-4-one | 62321-81-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 6-Heptafluoropropyl-3-hydroxy-3-methyl-2,3-dihydro-pyran-4-one
• 英文别名: 4H-Pyran-4-one, 6-(heptafluoropropyl)-2,3-dihydro-3-hydroxy-3-methyl-；6-(1,1,2,2,3,3,3-heptafluoropropyl)-3-hydroxy-3-methyl-2H-pyran-4-one
• CAS: 62321-81-7
• 化学式: C₉H₇F₇O₃
• 分子量: 296.142
• InChiKey: YYVWPBDZYMJZGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  6-Heptafluoropropyl-3-hydroxy-3-methyl-2,3-dihydro-pyran-4-one 在 吡啶 、 磺酰氯 作用下， 生成 2-Heptafluoropropyl-5-methyl-pyran-4-one 、 3-Chloro-6-heptafluoropropyl-3-methyl-2,3-dihydro-pyran-4-one
  参考文献：
  名称：

  New synthetic approaches to 2-perfluoroalkyl-4H-pyran-4-ones

  摘要：

  A convenient synthesis of 5-substituted 2-perfluoroalkyl-4H-pyran-4-ones by dehydration of 2,3-dihydro-3-hydroxy-6-perfluoroalkyl-4H-pyran-4-ones is described. The 6-substituted and parent 2-perfluoroalkyl-4H-pyran-4-ones have been more successfully prepared using the condensation of alkyl enol ethers, derived from beta-dicarbonyl compounds, with ethyl perfluoroalkanoates. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)83018-4

文献信息

• New synthetic approaches to 2-perfluoroalkyl-4H-pyran-4-ones
  作者：Vladimir I. Tyvorskii、Denis N. Bobrov、Oleg G. Kulinkovich、Norbert De Kimpe、Kourosch Abbaspour Tehrani

  DOI：10.1016/s0040-4020(98)83018-4

  日期：1998.3

  A convenient synthesis of 5-substituted 2-perfluoroalkyl-4H-pyran-4-ones by dehydration of 2,3-dihydro-3-hydroxy-6-perfluoroalkyl-4H-pyran-4-ones is described. The 6-substituted and parent 2-perfluoroalkyl-4H-pyran-4-ones have been more successfully prepared using the condensation of alkyl enol ethers, derived from beta-dicarbonyl compounds, with ethyl perfluoroalkanoates. (C) 1998 Elsevier Science Ltd. All rights reserved.