(2S,4S)-2-amino-4-methylhexanedioic acid | 93667-68-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4S)-2-amino-4-methylhexanedioic acid
• 英文别名: Hexanedioic acid, 2-amino-4-methyl-, (2S,4S)-
• CAS: 93667-68-6
• 化学式: C₇H₁₃NO₄
• 分子量: 175.185
• InChiKey: ZFDGWQCTFBXNDM-WHFBIAKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 盐酸 作用下， 反应 48.0h， 以10 mg的产率得到(2S,4S)-2-amino-4-methylhexanedioic acid
  参考文献：
  名称：

  Isogai, Akira; Suzuki, Akinori; Tamura, Saburo, Journal of the Chemical Society. Perkin transactions I, 1984, # 7, p. 1405 - 1411

  摘要：

  DOI：

文献信息

• Alpha-aminoadipate for treatment of vision loss and restoring sight
  申请人：The Schepens Eye Research Institute, Inc.

  公开号：US10780070B2

  公开（公告）日：2020-09-22

  The invention provides compositions and methods for preserving, restoring, or enhancing vision of a subject by administering compositions to an injured or diseased eye.

  本发明提供了通过向受伤或患病的眼睛施用组合物来保护、恢复或增强受试者视力的组合物和方法。
• Methods and compositions for promoting axon regeneration and cell replacement therapy
  申请人：Chen Feng Dong

  公开号：US20050152995A1

  公开（公告）日：2005-07-14

  Provided herein are methods and compositions for rendering a cellular environment permissive to axon regeneration and neural cell transplantation. Methods for stimulating axon regeneration in adult subjects are also disclosed. The methods may comprise contacting a tissue with an agent that prevents glial scar formation, such as by inhibiting reactive astroglial cells, and optionally an agent that increases bcl-2 protein levels in neural cells. Exemplary agents include astrotoxin for inhibiting reactive astroglial cells and lithium for increasing bcl-2 protein levels.

  本文提供了使细胞环境有利于轴突再生和神经细胞移植的方法和组合物。还公开了刺激成人轴突再生的方法。这些方法可包括使组织接触一种防止神经胶质疤痕形成的制剂，例如通过抑制反应性星形胶质细胞，以及可选的一种增加神经细胞中 bcl-2 蛋白水平的制剂。示例药剂包括抑制反应性星形胶质细胞的星形毒素和提高 bcl-2 蛋白水平的锂。
• Alpha-Aminoadipate For Treatment Of Vision Loss And Restoring Sight
  申请人：THE SCHEPENS EYE RESEARCH INSTITUTE, INC.

  公开号：US20160271091A1

  公开（公告）日：2016-09-22

  The invention provides compositions and methods for preserving, restoring, or enhancing vision of a subject by administering compositions to an injured or diseased eye.
• ALPHA-AMINOADIPATE FOR TREATMENT OF VISION LOSS AND RESTORING SIGHT
  申请人：The Schepens Eye Research Institute, Inc.

  公开号：US20210059969A1

  公开（公告）日：2021-03-04

  The invention provides compositions and methods for preserving, restoring, or enhancing vision of a subject by administering compositions to an injured or diseased eye.