(4S,5S)-4-p-tolylthio-5-trifluoromethyldihydrofuran-2-one | 473435-95-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (4S,5S)-4-p-tolylthio-5-trifluoromethyldihydrofuran-2-one
• 英文别名: (4S,5S)-4-(4-methylphenyl)sulfanyl-5-(trifluoromethyl)oxolan-2-one
• CAS: 473435-95-9
• 化学式: C₁₂H₁₁F₃O₂S
• 分子量: 276.279
• InChiKey: WQKKYWCEVHFPEL-GXSJLCMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (4S,5S)-4-p-tolylthio-5-trifluoromethyldihydrofuran-2-one 在 镍 氢气 作用下， 以 乙二醇 为溶剂， 反应 2.0h， 以62%的产率得到(-)-(R)-5-三氟甲基二氢呋喃-2-酮
  参考文献：
  名称：

  Stereoselective Synthesis of Both Enantiomers of Trifluoro-γ-valerolactone and Pentafluoro-γ-caprolactone

  摘要：

  Both enantiomers of 5-(trifluoromethyl)dihydrofuran-2-one (1a) and 5-(pentafluoroethyl)dihydrofuran-2-one (1b) have been synthesised stereoselectively, in four steps, starting from chiral (R)- or (S)-3-[(4-methylphenyl)sulfinyl]propionic acid (2) and commercially available perfluorinated esters. Compound (+)-(S)-1b is the pentafluoro analogue of the aggregation pheromone of Trogoderma glabrum.

  DOI：

  10.1002/1099-0690(200206)2002:12<1895::aid-ejoc1895>3.0.co;2-1
• 作为产物：
  描述：

  (3S,4S)-5,5,5-trifluoro-4-hydroxy-3-(p-tolylthio)pentanoic acid 在 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以73.2%的产率得到(4S,5S)-4-p-tolylthio-5-trifluoromethyldihydrofuran-2-one
  参考文献：
  名称：

  Stereoselective Synthesis of Both Enantiomers of Trifluoro-γ-valerolactone and Pentafluoro-γ-caprolactone

  摘要：

  Both enantiomers of 5-(trifluoromethyl)dihydrofuran-2-one (1a) and 5-(pentafluoroethyl)dihydrofuran-2-one (1b) have been synthesised stereoselectively, in four steps, starting from chiral (R)- or (S)-3-[(4-methylphenyl)sulfinyl]propionic acid (2) and commercially available perfluorinated esters. Compound (+)-(S)-1b is the pentafluoro analogue of the aggregation pheromone of Trogoderma glabrum.

  DOI：

  10.1002/1099-0690(200206)2002:12<1895::aid-ejoc1895>3.0.co;2-1

文献信息

• Stereoselective Synthesis of Both Enantiomers of Trifluoro-γ-valerolactone and Pentafluoro-γ-caprolactone
  作者：Pierfrancesco Bravo、Massimo Frigerio、Alfonso Melloni、Walter Panzeri、Cristina Pesenti、Fiorenza Viani、Matteo Zanda

  DOI：10.1002/1099-0690(200206)2002:12<1895::aid-ejoc1895>3.0.co;2-1

  日期：2002.6

  Both enantiomers of 5-(trifluoromethyl)dihydrofuran-2-one (1a) and 5-(pentafluoroethyl)dihydrofuran-2-one (1b) have been synthesised stereoselectively, in four steps, starting from chiral (R)- or (S)-3-[(4-methylphenyl)sulfinyl]propionic acid (2) and commercially available perfluorinated esters. Compound (+)-(S)-1b is the pentafluoro analogue of the aggregation pheromone of Trogoderma glabrum.