1-(3-hydroxyphenyl)-2-phenyl-cyclopropane | 219521-11-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(3-hydroxyphenyl)-2-phenyl-cyclopropane
• 英文别名: 3-(2-Phenylcyclopropyl)phenol
• CAS: 219521-11-6
• 化学式: C₁₅H₁₄O
• 分子量: 210.276
• InChiKey: JNOCWDUBVFEJBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  methyl (2-(bromomethyl)phenyl)-N-methoxycarbamate 、 1-(3-hydroxyphenyl)-2-phenyl-cyclopropane 在 sodium hydroxide 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 以37%的产率得到methyl N-methoxy-N-[2-(3-(2-phenylcyclopropyl)-phenoxymethyl)-phenyl]carbamate
  参考文献：
  名称：

  Substituted cyclopropyl phenoxymethyl phenyl carbamates and their use as fungicides

  摘要：

  提供具有杀真菌特性的化合物，其公式为其中m和n为0或1；X为氢、卤素、(C1-C4)烷基或烷氧基；Z为(C1-C12)烷基或卤代烷基；R、R1、R2、R3和R4独立地为氢、卤素、较低烷基、烯基、炔基、烷氧基、环烷基、芳基、芳基环烷基或杂环基，可选择地取代一个或多个卤素原子。

  公开号：

  EP0924197A1
• 作为产物：
  描述：

  5-(3-hydroxyphenyl)-3-phenyl-2-pyrazoline 在 sodium hydroxide 作用下， 以 水 为溶剂， 以58%的产率得到1-(3-hydroxyphenyl)-2-phenyl-cyclopropane
  参考文献：
  名称：

  Substituted cyclopropyl phenoxymethyl phenyl carbamates and their use as

  摘要：

  具有杀真菌性能的化合物具有以下结构式 ##STR1## 其中 m 和 n 为 0 或 1；X 为氢、卤素、C.sub.1 -C.sub.4) 烷基或烷氧基；Z 为 (C.sub.1 -C.sub.12) 烷基或卤代烷基；R、R.sub.1、R.sub.2、R.sub.3 和 R.sub.4 独立地为氢、卤素、较低烷基、烯基、炔基、烷氧基、环烷基、芳基、芳基环烷基或杂环烷基，可以选择地取代一个或多个卤素原子。

  公开号：

  US06022891A1
• 作为试剂：
  描述：

  5-(3-hydroxyphenyl)-3-phenyl-2-pyrazoline 、 sodium hydroxide 、 盐酸 在 氮气 、 乙醚 、 水 、 氯化钠 、 magnesium sulfate 、 crude product 、 silica gel 、 乙酸乙酯 、 正己烷 、 1-(3-hydroxyphenyl)-2-phenyl-cyclopropane 作用下， 以 水 为溶剂， 反应 2.0h， 以to afford 1.8 g of the title compound 1-(3-hydroxyphenyl)-2-phenyl-cyclopropane as a pale yellow liquid in a 58% yield的产率得到1-(3-hydroxyphenyl)-2-phenyl-cyclopropane
  参考文献：
  名称：

  Substituted cyclopropyl phenoxymethyl phenyl carbamates and their use as

  摘要：

  提供具有杀真菌特性的化合物，其化学式为##STR1##其中m和n为0或1；X为氢，卤素，(C.sub.1-C.sub.4)烷基或烷氧基；Z为(C.sub.1-C.sub.12)烷基或卤代烷基；R、R.sub.1、R.sub.2、R.sub.3和R.sub.4独立地为氢、卤素、低烷基、烯基、炔基、烷氧基、环烷基、芳基、芳基环烷基或杂环基，可以选择地被一个或多个卤素原子取代。

  公开号：

  US06114375A1

文献信息

• Benzyloxy substituted aromatics and their use as fungicides and
  申请人：Rohm and Haas Company

  公开号：US05945557A1

  公开（公告）日：1999-08-31

  Compounds with fungicidal and insecticidal properties having formula ##STR1## wherein A is N or CH; V is O or NH; m and n are the integers 0 and 1, provided that m+n is 0 or 1; X is independently selected from hydrogen, halo, (C.sub.1 -C.sub.4)alkyl, and (C.sub.1 -C.sub.4)alkoxy; R is independently selected from hydrogen, (C.sub.1 -C.sub.12)alkyl, (C.sub.1 -C.sub.12)alkoxy, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.2 -C.sub.12)alkenyl, (C.sub.2 -C.sub.12)alkynyl, (C.sub.1 -C.sub.12)alkoxy(C.sub.1 -C.sub.12)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, halo(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.12)alkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.2 -C.sub.12)alkenyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.2 -C.sub.12)alkynyl, (C.sub.1 -C.sub.12)alkyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.1 -C.sub.12)alkoxy(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.1 -C.sub.12)alkoxy(C.sub.1 -C.sub.12)alkyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.2 -C.sub.12)alkenyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.2 -C.sub.12)alkynyl(C.sub.3 -C.sub.7)cycloalkyl, halo(C.sub.1 -C.sub.12)alkyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.1 -C.sub.12)alkoxy(C.sub.2 -C.sub.12)alkenyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.1 -C.sub.12)alkoxy(C.sub.2 -C.sub.12)alkynyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.1 -C.sub.12)alkyl(C.sub.3 -C.sub.7)cycloalkyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.2 -C.sub.12)alkenyl(C.sub.3 -C.sub.7)cycloalkyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.2 -C.sub.12)alkynyl(C.sub.3 -C.sub.7)cycloalkyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.12)alkyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.2 -C.sub.12)alkenyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.2 -C.sub.12)alkynyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.12)alkoxy(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.12)alkoxy(C.sub.1 -C.sub.12)alkyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.12)alkoxy(C.sub.1 -C.sub.12)alkenyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.12)alkoxy(C.sub.1 -C.sub.12)alkynyl(C.sub.3 -C.sub.7)cycloalkyl, aryl, aralkyl, aryl(C.sub.3 -C.sub.7)cycloalkyl, aryl(C.sub.3 -C.sub.7)cycloalkyl(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkylaryl, aryl(C.sub.1 -C.sub.4)alkyl(C.sub.3 -C.sub.7)cycloalkyl, heterocyclic, aryl(C.sub.1 -C.sub.4)alkylheterocyclic heterocyclic(C.sub.1 -C.sub.4)alkyl, heterocyclic(C.sub.3 -C.sub.7)cycloalkyl and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently selected from hydrogen, halogen, (C.sub.1 -C.sub.12)alkyl, (C.sub.1 -C.sub.12)alkoxy, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.2 -C.sub.12)alkenyl, (C.sub.2 -C.sub.12)alkynyl, (C.sub.3 -C.sub.7)cycloalkyl, cyano, carboxy, (C.sub.1 -C.sub.4)alkoxycarbonyl, aryl, and when taken together R.sub.2 and R.sub.3 form a (C.sub.3 -C.sub.7)cycloalkyl ring, provided that when n=0 or 1 and m=0 R and R.sub.1 are not both hydrogen and when A is N and V is NH and n and m are both zero than R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are other than 1 to 3 substituents independently selected from halogen and (C.sub.1 -C.sub.4)alkyl.

  具有杀菌和杀虫性质的化合物的化学式为##STR1##其中A为N或CH；V为O或NH；m和n为整数0和1，前提是m+n为0或1；X独立地选自氢，卤素，（C.sub.1-C.sub.4）烷基和（C.sub.1-C.sub.4）氧烷基；R独立地选自氢，（C.sub.1-C.sub.12）烷基，（C.sub.1-C.sub.12）氧烷基，卤素（C.sub.1-C.sub.12）烷基，（C.sub.2-C.sub.12）烯基，（C.sub.2-C.sub.12）炔基，（C.sub.1-C.sub.12）氧烷基（C.sub.1-C.sub.12）烷基，（C.sub.3-C.sub.7）环烷基，卤素（C.sub.3-C.sub.7）环烷基，（C.sub.3-C.sub.7）环烷基（C.sub.1-C.sub.12）烷基，（C.sub.3-C.sub.7）环烷基（C.sub.2-C.sub.12）烯基，（C.sub.3-C.sub.7）环烷基（C.sub.2-C.sub.12）炔基，（C.sub.1-C.sub.12）烷基（C.sub.3-C.sub.7）环烷基，（C.sub.1-C.sub.12）氧烷基（C.sub.3-C.sub.7）环烷基，（C.sub.1-C.sub.12）氧烷基（C.sub.1-C.sub.12）烷基（C.sub.3-C.sub.7）环烷基，（C.sub.2-C.sub.12）烯基（C.sub.3-C.sub.7）环烷基，（C.sub.2-C.sub.12）炔基（C.sub.3-C.sub.7）环烷基，卤素（C.sub.1-C.sub.12）烷基（C.sub.3-C.sub.7）环烷基，（C.sub.1-C.sub.12）氧烷基（C.sub.2-C.sub.12）烯基（C.sub.3-C.sub.7）环烷基，（C.sub.1-C.sub.12）氧烷基（C.sub.2-C.sub.12）炔基（C.sub.3-C.sub.7）环烷基，（C.sub.3-C.sub.7）环烷基（C.sub.3-C.sub.7）环烷基，（C.sub.1-C.sub.12）烷基（C.sub.3-C.sub.7）环烷基（C.sub.3-C.sub.7）环烷基，（C.sub.2-C.sub.12）烯基（C.sub.3-C.sub.7）环烷基（C.sub.3-C.sub.7）环烷基，（C.sub.2-C.sub.12）炔基（C.sub.3-C.sub.7）环烷基（C.sub.3-C.sub.7）环烷基，（C.sub.3-C.sub.7）环烷基（C.sub.1-C.sub.12）烷基（C.sub.3-C.sub.7）环烷基，（C.sub.3-C.sub.7）环烷基（C.sub.2-C.sub.12）烯基（C.sub.3-C.sub.7）环烷基，（C.sub.3-C.sub.7）环烷基（C.sub.2-C.sub.12）炔基（C.sub.3-C.sub.7）环烷基，（C.sub.3-C.sub.7）环烷基（C.sub.1-C.sub.12）氧烷基（C.sub.3-C.sub.7）环烷基，（C.sub.3-C.sub.7）环烷基（C.sub.1-C.sub.12）氧烷基（C.sub.1-C.sub.12）烷基（C.sub.3-C.sub.7）环烷基，（C.sub.3-C.sub.7）环烷基（C.sub.1-C.sub.12）氧烷基（C.sub.1-C.sub.12）烯基（C.sub.3-C.sub.7）环烷基，（C.sub.3-C.sub.7）环烷基（C.sub.1-C.sub.12）氧烷基（C.sub.1-C.sub.12）炔基（C.sub.3-C.sub.7）环烷基，芳基，芳基烷基，芳基（C.sub.3-C.sub.7）环烷基，芳基（C.sub.3-C.sub.7）环烷基（C.sub.3-C.sub.7）环烷基，（C.sub.3-C.sub.7）环烷基芳基，芳基（C.sub.1-C.sub.4）烷基（C.sub.3-C.sub.7）环烷基，杂环，芳基（C.sub.1-C.sub.4）烷基杂环，杂环（C.sub.1-C.sub.4）烷基，杂环（C.sub.3-C.sub.7）环烷基和R.sub.1、R.sub.2、R.sub.3和R.sub.4独立地选自氢，卤素，（C.sub.1-C.sub.12）烷基，（C.sub.1-C.sub.12）氧烷基，卤素（C.sub.1-C.sub.12）烷基，（C.sub.2-C.sub.12）烯基，（C.sub.2-C.sub.12）炔基，（C.sub.3-C.sub.7）环烷基，氰基，羧基，（C.sub.1-C.sub.4）烷氧羰基，芳基，当R.sub.2和R.sub.3组成（C.sub.3-C.sub.7）环烷基环时，可以选择，前提是当n=0或1且m=0时，R和R.sub.1不同时为氢，当A为N且V为NH且n和m都为零时，R、R.sub.1、R.sub.2、R.sub.3和R.sub.4均不为1到3个独立选自卤素和（C.sub.1-C.sub.4）烷基的取代基。
• Substituted cyclopropyl phenoxymethyl phenyl carbamates and their use as fungicides
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0924197A1

  公开（公告）日：1999-06-23

  Compounds with fungicidal properties are presented having the formula wherein m and n are 0 or 1; X is hydrogen, halo, (C1-C4)alkyl or alkoxy; Z is (C1-C12) alkyl or haloalkyl; R, R1, R2, R3, and R4 are independently hydrogen, a halogen, lower alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, arylcycloalkyl, or heterocyclyl, optionally substituted with one or more halogen atoms.

  提供具有杀真菌特性的化合物，其公式为其中m和n为0或1；X为氢、卤素、(C1-C4)烷基或烷氧基；Z为(C1-C12)烷基或卤代烷基；R、R1、R2、R3和R4独立地为氢、卤素、较低烷基、烯基、炔基、烷氧基、环烷基、芳基、芳基环烷基或杂环基，可选择地取代一个或多个卤素原子。
• Benzyloxy substituted aromatics and their use as fungicides and insecticides
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0889024B1

  公开（公告）日：2000-09-13
• US5945557A
  申请人：——

  公开号：US5945557A

  公开（公告）日：1999-08-31
• US6022891A
  申请人：——

  公开号：US6022891A

  公开（公告）日：2000-02-08