1-Methoxy-3-methyl-5-(trifluoromethoxy)benzene | 1000339-56-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Methoxy-3-methyl-5-(trifluoromethoxy)benzene
• CAS: 1000339-56-9
• 化学式: C₉H₉F₃O₂
• 分子量: 206.16
• InChiKey: LCNOEWBAXFSPOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PHOTOREACTIVE COMPOUNDS
  申请人：Lincker Frederic

  公开号：US20140192305A1

  公开（公告）日：2014-07-10

  The present invention relates to photoreactive compounds that are particularly useful in materials for the alignment of liquid crystals.

  本发明涉及光反应性化合物，特别适用于液晶对准材料的制作。
• [EN] 2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES<br/>[FR] COMPOSÉS DE 2-PYRIDAZIN-3(2H)-ONE À SUBSTITUTION 2-ARYLE ET 2-HÉTÉROARYLE UTILISÉS EN TANT QU'INHIBITEURS DE FGFR TYROSINE KINASES
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2017070708A1

  公开（公告）日：2017-04-27

  Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X, R1, R2, R3, Ring A and z have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.

  本文提供了一般式I的化合物及其立体异构体和药学上可接受的盐或溶剂，其中X、R1、R2、R3、环A和z的含义如规范中所述，这些化合物是FGFR1、FGFR2、FGFR3和/或FGFR4的抑制剂，可用于治疗和预防可以用FGFR抑制剂治疗的疾病，包括由FGFR1、FGFR2、FGFR3和/或FGFR4介导的疾病或障碍。
• SUBSTITUTED GEMCITABINE ARYL AMIDE ANALOGS
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：US20150259375A1

  公开（公告）日：2015-09-17

  In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating viral disorders and disorders of uncontrolled cellular proliferation using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  这项发明涉及替代gemcitabine芳基酰胺类似物、其衍生物和相关化合物；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗病毒性疾病和细胞不受控制增殖的疾病的方法。本摘要旨在作为搜索特定领域的工具，不限制本发明。
• SUBSTITUTED SPIROPIPERIDINYL COMPOUNDS USEFUL AS GPR120 AGONISTS
  申请人：CHELLIAH Mariappan

  公开号：US20150274672A1

  公开（公告）日：2015-10-01

  The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

  本发明涉及一种由公式(I)表示的化合物及其药学上可接受的盐，用于治疗或预防糖尿病、高脂血症、肥胖症、与炎症相关的疾病和相关疾病和状况。该化合物是G蛋白偶联受体GPR120的激动剂，是有用的。还包括药物组成物和治疗方法。
• Fused heterocyclic compounds, and compositions and uses thereof
  申请人：Kelly Michael G.

  公开号：US20100317676A1

  公开（公告）日：2010-12-16

  Fused heterocyclic compounds are disclosed that have formula 1: where A, B, L, N, R 1 , R 3 , R 4′ , Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  本文披露了具有1式的融合杂环化合物，其中A、B、L、N、R1、R3、R4'、Y和Z的定义如本文所述。这些化合物及其制剂对哺乳动物，包括人类，的多种疾病的预防和治疗有用，包括但不限于疼痛、炎症、认知障碍、焦虑、抑郁等。