3-cyano-2-cyanomethylthio-6-phenyl-4-(3'-pyridyl)pyridine | 247056-26-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-cyano-2-cyanomethylthio-6-phenyl-4-(3'-pyridyl)pyridine
• 英文别名: 2-(Cyanomethylsulfanyl)-6-phenyl-4-pyridin-3-ylpyridine-3-carbonitrile
• CAS: 247056-26-4
• 化学式: C₁₉H₁₂N₄S
• 分子量: 328.397
• InChiKey: MDAIQUWZQAUMDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  98.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-cyano-2-cyanomethylthio-6-phenyl-4-(3'-pyridyl)pyridine 在 sodium methylate 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 0.08h， 以90%的产率得到3-amino-2-cyano-6-phenyl-4-(3'-pyridyl)-thieno[2,3-b]pyridine
  参考文献：
  名称：

  Derivatives of 3-cyano-6-phenyl-4-(3`-pyridyl)-pyridine-2(1H)-thione and their neurotropic activity

  摘要：

  3-Cyano-6-phenyl-4-(3'-pyridyl)pyridine-2(1H)-thione, the related 2,2'-bis-pyridyldisulfide, 2-alkylthiopyridines and 2-aminothieno[2,3-b]pyridines were synthesised and their neurotropic activities were examined. Bispyridyldisulfide exhibited low toxicity (LD50 > 5 000 mg/kg, ICR mice, i.p.) and selective antiamesic activity at the doses of 0.05-0.5 mg/kg p.o. This effect was significantly higher than that induced by Piracetam at 50 mg/kg. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80081-6
• 作为产物：
  描述：

  (E)-1-Phenyl-3-pyrid-3-yl-propenon 以 乙醇 为溶剂， 生成 3-cyano-2-cyanomethylthio-6-phenyl-4-(3'-pyridyl)pyridine
  参考文献：
  名称：

  Derivatives of 3-cyano-6-phenyl-4-(3`-pyridyl)-pyridine-2(1H)-thione and their neurotropic activity

  摘要：

  3-Cyano-6-phenyl-4-(3'-pyridyl)pyridine-2(1H)-thione, the related 2,2'-bis-pyridyldisulfide, 2-alkylthiopyridines and 2-aminothieno[2,3-b]pyridines were synthesised and their neurotropic activities were examined. Bispyridyldisulfide exhibited low toxicity (LD50 > 5 000 mg/kg, ICR mice, i.p.) and selective antiamesic activity at the doses of 0.05-0.5 mg/kg p.o. This effect was significantly higher than that induced by Piracetam at 50 mg/kg. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80081-6

文献信息

• Derivatives of 3-cyano-6-phenyl-4-(3`-pyridyl)-pyridine-2(1H)-thione and their neurotropic activity
  作者：Aivars Krauze、Skaidrite Ģērmane、Ojārs Eberlin |nE š、Igors Šturms、Vija Klusā、Gunárs Duburs

  DOI：10.1016/s0223-5234(99)80081-6

  日期：1999.4

  3-Cyano-6-phenyl-4-(3'-pyridyl)pyridine-2(1H)-thione, the related 2,2'-bis-pyridyldisulfide, 2-alkylthiopyridines and 2-aminothieno[2,3-b]pyridines were synthesised and their neurotropic activities were examined. Bispyridyldisulfide exhibited low toxicity (LD50 > 5 000 mg/kg, ICR mice, i.p.) and selective antiamesic activity at the doses of 0.05-0.5 mg/kg p.o. This effect was significantly higher than that induced by Piracetam at 50 mg/kg. (C) Elsevier, Paris.