(2Z,4Z,6Z)-8,8-dimethyl-2,4-bis(phenylthio)nona-1,4,6-trienal ethyl acetal | 213456-92-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (2Z,4Z,6Z)-8,8-dimethyl-2,4-bis(phenylthio)nona-1,4,6-trienal ethyl acetal
• 英文别名: [(2Z,4Z,6Z)-1,1-diethoxy-8,8-dimethyl-2,6-bis(phenylsulfanyl)nona-2,4,6-trien-4-yl]sulfanylbenzene
• CAS: 213456-92-9
• 化学式: C₃₃H₃₈O₂S₃
• 分子量: 562.862
• InChiKey: WYCVJMQTGJVYQL-NVIRJLRDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.8
• 重原子数：
  38
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  94.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-苯基-1-三甲基硅氧乙烯 、 (2Z,4Z,6Z)-8,8-dimethyl-2,4-bis(phenylthio)nona-1,4,6-trienal ethyl acetal 在 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 以56%的产率得到(4Z,6Z,8Z)-3-Ethoxy-10,10-dimethyl-1-phenyl-4,6,8-tris-phenylsulfanyl-undeca-4,6,8-trien-1-one
  参考文献：
  名称：

  A New 1-Alkoxy-2-(chalcogeno)allylic or 1-Alkoxy-2,4-bis(chalcogeno)penta-2,4-dienyl Cation:  Highly-Regioselective Allylating or Penta-2,4-dienylating Electrophiles and Their Reactions

  摘要：

  2-(Chalcogeno)-1-ethoxyallylic cations 4A are easily generated from the reactions of 2-(chalcogeno)-1-ethoxyprop-1-en-3-ols 2a-e or 2-(chalcogeno)prop-2-enal acetals 3a-c and TMSOTf and reacted with various nucleophiles to give the adducts 5a-8a, 5b-11b, and 5c-e regio and stereoselectively. 2,4-Bis(chalcogeno)penta-2,4-dienal acetals 16a,c and the 2,4,6-tris(phenylthio)hepta-2,4,6-trienal acetal 20c also gave the dienones 17a,c and 21c in good yields. Furthermore, the intramolecular cyclization of the alkenyl alcohols 25a,b and the 2,4-dienal 2,4-dinitrophenyl hydrazones 29a-c afforded the tetrahydrofurans 26a,b and 3,5-bis(chalcogeno)pyridines 30a-c, respectively.

  DOI：

  10.1021/jo9807767
• 作为产物：
  描述：

  (Z)-1-Ethoxy-4,4-dimethyl-2-phenylsulfanyl-pent-1-en-3-ol 在 正丁基锂 、 三氟甲磺酸三甲基硅酯 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 0.17h， 生成 (2Z,4Z,6Z)-8,8-dimethyl-2,4-bis(phenylthio)nona-1,4,6-trienal ethyl acetal
  参考文献：
  名称：

  A New 1-Alkoxy-2-(chalcogeno)allylic or 1-Alkoxy-2,4-bis(chalcogeno)penta-2,4-dienyl Cation:  Highly-Regioselective Allylating or Penta-2,4-dienylating Electrophiles and Their Reactions

  摘要：

  2-(Chalcogeno)-1-ethoxyallylic cations 4A are easily generated from the reactions of 2-(chalcogeno)-1-ethoxyprop-1-en-3-ols 2a-e or 2-(chalcogeno)prop-2-enal acetals 3a-c and TMSOTf and reacted with various nucleophiles to give the adducts 5a-8a, 5b-11b, and 5c-e regio and stereoselectively. 2,4-Bis(chalcogeno)penta-2,4-dienal acetals 16a,c and the 2,4,6-tris(phenylthio)hepta-2,4,6-trienal acetal 20c also gave the dienones 17a,c and 21c in good yields. Furthermore, the intramolecular cyclization of the alkenyl alcohols 25a,b and the 2,4-dienal 2,4-dinitrophenyl hydrazones 29a-c afforded the tetrahydrofurans 26a,b and 3,5-bis(chalcogeno)pyridines 30a-c, respectively.

  DOI：

  10.1021/jo9807767

文献信息

• A New 1-Alkoxy-2-(chalcogeno)allylic or 1-Alkoxy-2,4-bis(chalcogeno)penta-2,4-dienyl Cation:  Highly-Regioselective Allylating or Penta-2,4-dienylating Electrophiles and Their Reactions
  作者：Mitsuhiro Yoshimatsu、Satoshi Gotoh、Kazunari Ikeda、Motonori Komori

  DOI：10.1021/jo9807767

  日期：1998.9.1

  2-(Chalcogeno)-1-ethoxyallylic cations 4A are easily generated from the reactions of 2-(chalcogeno)-1-ethoxyprop-1-en-3-ols 2a-e or 2-(chalcogeno)prop-2-enal acetals 3a-c and TMSOTf and reacted with various nucleophiles to give the adducts 5a-8a, 5b-11b, and 5c-e regio and stereoselectively. 2,4-Bis(chalcogeno)penta-2,4-dienal acetals 16a,c and the 2,4,6-tris(phenylthio)hepta-2,4,6-trienal acetal 20c also gave the dienones 17a,c and 21c in good yields. Furthermore, the intramolecular cyclization of the alkenyl alcohols 25a,b and the 2,4-dienal 2,4-dinitrophenyl hydrazones 29a-c afforded the tetrahydrofurans 26a,b and 3,5-bis(chalcogeno)pyridines 30a-c, respectively.