2-({2-[(Z)-Hydroxyimino]-2-phenyl-ethyl}-p-tolyl-amino)-1-phenyl-ethanone oxime | 248583-84-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-({2-[(Z)-Hydroxyimino]-2-phenyl-ethyl}-p-tolyl-amino)-1-phenyl-ethanone oxime
• 英文别名: (NZ)-N-[2-(N-[(2Z)-2-hydroxyimino-2-phenylethyl]-4-methylanilino)-1-phenylethylidene]hydroxylamine
• CAS: 248583-84-8
• 化学式: C₂₃H₂₃N₃O₂
• 分子量: 373.455
• InChiKey: MCVUFCKFMJHCQC-BQASJOSNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  68.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  对甲氧基苯异氰酸酯 、 2-({2-[(Z)-Hydroxyimino]-2-phenyl-ethyl}-p-tolyl-amino)-1-phenyl-ethanone oxime 以 乙腈 为溶剂， 反应 21.0h， 以49%的产率得到1-(4-Methoxyphenyl)-6-(4-methylphenyl)-7a-phenyl-5,7-dihydroimidazo[1,5-b][1,2,4]oxadiazol-2-one
  参考文献：
  名称：

  Beckmann Fragmentation of Diphenylcarbamoylated N-Aryldiphenacylamine Dioximes. New Method for the Synthesis of Imidazooxadiazolones

  摘要：

  N-Aryl-N,N-diphenacylamine dioximes were prepared by the reaction of corresponding arylamines with alpha-bromoacetophenone oxime in ethanol-water at room temperature. These compounds reacted with aryl isocyanates in acetonitrile to give imidazooxadiazolones 9. The probable mechanism of the reaction is discussed.

  DOI：

  10.1080/00397919908085909
• 作为产物：
  描述：

  乙烷,三氯氟- 、 α-bromoacetophenone oxime 以 乙醇 为溶剂， 反应 6.0h， 以98%的产率得到2-({2-[(Z)-Hydroxyimino]-2-phenyl-ethyl}-p-tolyl-amino)-1-phenyl-ethanone oxime
  参考文献：
  名称：

  Beckmann Fragmentation of Diphenylcarbamoylated N-Aryldiphenacylamine Dioximes. New Method for the Synthesis of Imidazooxadiazolones

  摘要：

  N-Aryl-N,N-diphenacylamine dioximes were prepared by the reaction of corresponding arylamines with alpha-bromoacetophenone oxime in ethanol-water at room temperature. These compounds reacted with aryl isocyanates in acetonitrile to give imidazooxadiazolones 9. The probable mechanism of the reaction is discussed.

  DOI：

  10.1080/00397919908085909

文献信息

• Beckmann Fragmentation of Diphenylcarbamoylated N-Aryldiphenacylamine Dioximes. New Method for the Synthesis of Imidazooxadiazolones
  作者：Necdet Coşkun、Fatma Tirli Tat、Özden Özel Güven

  DOI：10.1080/00397919908085909

  日期：1999.11

  N-Aryl-N,N-diphenacylamine dioximes were prepared by the reaction of corresponding arylamines with alpha-bromoacetophenone oxime in ethanol-water at room temperature. These compounds reacted with aryl isocyanates in acetonitrile to give imidazooxadiazolones 9. The probable mechanism of the reaction is discussed.