(2R,3R)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-nitro-4-trifluoromethanesulfonyloxy-phenyl)-propionic acid methyl ester | 192328-65-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R,3R)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-nitro-4-trifluoromethanesulfonyloxy-phenyl)-propionic acid methyl ester
• 英文别名: methyl (2R,3R)-3-[tert-butyl(dimethyl)silyl]oxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[3-nitro-4-(trifluoromethylsulfonyloxy)phenyl]propanoate
• CAS: 192328-65-7
• 化学式: C₂₂H₃₃F₃N₂O₁₀SSi
• 分子量: 602.658
• InChiKey: YXHHBGILVFYKKU-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.95
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  171
• 氢给体数：
  1
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  (2R,3R)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-nitro-4-trifluoromethanesulfonyloxy-phenyl)-propionic acid methyl ester 在 lithium hydroxide 作用下， 以86%的产率得到(2R,3R)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-nitro-4-trifluoromethanesulfonyloxy-phenyl)-propionic acid
  参考文献：
  名称：

  Synthesis of the Vancomycin CD and DE Ring Systems

  摘要：

  Full details of the synthesis of the fully substituted vancomycin CD and DE ring systems are described and a potential solution to the control of the atropisomer stereochemistry is defined.

  DOI：

  10.1021/jo970560p
• 作为产物：
  描述：

  叔丁基二甲硅基三氟甲磺酸酯 生成 (2R,3R)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-nitro-4-trifluoromethanesulfonyloxy-phenyl)-propionic acid methyl ester
  参考文献：
  名称：

  Synthesis of the Vancomycin CD and DE Ring Systems

  摘要：

  Full details of the synthesis of the fully substituted vancomycin CD and DE ring systems are described and a potential solution to the control of the atropisomer stereochemistry is defined.

  DOI：

  10.1021/jo970560p

文献信息

• Synthesis of the Vancomycin CD and DE Ring Systems
  作者：Dale L. Boger、Robert M. Borzilleri、Seiji Nukui、Richard T. Beresis

  DOI：10.1021/jo970560p

  日期：1997.7.1

  Full details of the synthesis of the fully substituted vancomycin CD and DE ring systems are described and a potential solution to the control of the atropisomer stereochemistry is defined.