(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-(4-methylphenyl)-4-[(phenylamino)-carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-1-heptanoic acid | 693794-21-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-(4-methylphenyl)-4-[(phenylamino)-carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-1-heptanoic acid
• 英文别名: (3R,5R)-7-[2-(4-fluorophenyl)-3-(4-methylphenyl)-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
• CAS: 693794-21-7
• 化学式: C₃₄H₃₇FN₂O₅
• 分子量: 572.677
• InChiKey: DDGGZMGZFJOPOF-VSGBNLITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  42
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  112
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Substituted pyrrole derivatives
  申请人：——

  公开号：US20040102511A1

  公开（公告）日：2004-05-27

  The present invention relates to substituted pyrrole derivatives, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as, pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.

  本发明涉及取代吡咯衍生物，可用作3-羟基-3-甲基戊二酸辅酶A（HMG-CoA）还原酶抑制剂。本文披露的化合物可作为降胆固醇剂，并可用于治疗胆固醇相关疾病和相关症状。提供了制备披露化合物的过程，以及包含披露化合物的药物组合物，以及治疗胆固醇相关疾病和相关症状的方法。
• Atorvastatin derived HMG-CoA reductase degradation inducing compound
  申请人：UPPTHERA

  公开号：US11066391B1

  公开（公告）日：2021-07-20

  The present invention relates to bifunctional compounds that induce HMG-CoA reductase degradation, in which in which atorvastatin and E3 ubiquitin ligase binding moiety are chemically linked. The present invention also relates to a preparation method of the compounds, a method for degrading HMG-CoA reductase using the compounds, and a composition for the prevention or treatment of HMG-CoA reductase-related diseases comprising the compounds.

  本发明涉及诱导HMG-CoA还原酶降解的双功能化合物，其中阿托伐他汀和E3泛素连接酶结合分子通过化学连接。本发明还涉及该化合物的制备方法、使用该化合物降解HMG-CoA还原酶的方法，以及包含该化合物的用于预防或治疗HMG-CoA还原酶相关疾病的组合物。