4-Amino-N-pyridin-4-yl-butyramide; hydrochloride | 1374408-07-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Amino-N-pyridin-4-yl-butyramide; hydrochloride
• 英文别名: [4-Oxo-4-(pyridin-4-ylamino)butyl]azanium;chloride
• CAS: 1374408-07-7
• 化学式: C₉H₁₃N₃O*ClH
• 分子量: 215.683
• InChiKey: CGUVZEHCJNTGIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.18
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  [3-(Pyridin-4-ylcarbamoyl)-propyl]-carbamic acid tert-butyl ester 在 盐酸 作用下， 以 乙腈 为溶剂， 反应 36.0h， 以63%的产率得到4-Amino-N-pyridin-4-yl-butyramide; hydrochloride
  参考文献：
  名称：

  4-Aminopyridine derivatives with antiamnesic activity

  摘要：

  Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4-aminopyridine (4-AP). 4-AP is also the central ring of tacrine, the first drug approved for the treatment of AD. The synthesis and pharmacological activity of three 4-AP derivatives, prepared with the aim of improving their antiamnesic activity, is here described. In two of these compounds 4-AP is connected to 4-aminobutyric acid (GABA), whereas in the third it is connected to 2-indolinone, i.e., the skeleton of linopirdine, another Ach enhancing agent. The new compounds showed potent antiamnesic activity in comparison with piracetam. (C) 2000 Edition scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00103-3

文献信息

• 4-Aminopyridine derivatives with antiamnesic activity
  作者：A Andreani

  DOI：10.1016/s0223-5234(00)00103-3

  日期：2000.1

  Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4-aminopyridine (4-AP). 4-AP is also the central ring of tacrine, the first drug approved for the treatment of AD. The synthesis and pharmacological activity of three 4-AP derivatives, prepared with the aim of improving their antiamnesic activity, is here described. In two of these compounds 4-AP is connected to 4-aminobutyric acid (GABA), whereas in the third it is connected to 2-indolinone, i.e., the skeleton of linopirdine, another Ach enhancing agent. The new compounds showed potent antiamnesic activity in comparison with piracetam. (C) 2000 Edition scientifiques et medicales Elsevier SAS.