Cyclohexanemethanamine, 2-(3-methoxyphenyl)-, (1R,2R)- | 651312-71-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Cyclohexanemethanamine, 2-(3-methoxyphenyl)-, (1R,2R)-
• 英文别名: [(1R,2R)-2-(3-methoxyphenyl)cyclohexyl]methanamine
• CAS: 651312-71-9
• 化学式: C₁₄H₂₁NO
• 分子量: 219.32
• InChiKey: UMDGVFXQBMCYNZ-JSGCOSHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 1-Phenyl-2-dimethylaminomethyl cyclohexane compounds and therapies for depressive symptoms, pain and incontinence
  申请人：Friderichs Elmar

  公开号：US20050182131A1

  公开（公告）日：2005-08-18

  The invention relates to metabolites of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine as free bases and/or in the form of physiologically acceptable salts, corresponding medicaments, the use of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for producing a medicament used for treating depression, and related methods of treating depression.

  本发明涉及 [2-(3-甲氧基苯基)-环己基甲基]-二甲胺的代谢产物，作为自由碱基和/或生理上可接受的盐的形式，相应的药物、使用 [2-(3-甲氧基苯基)-环己基甲基]-二甲胺及其代谢产物用于制备用于治疗抑郁症的药物，以及相关的治疗抑郁症方法。
• C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorders
  申请人：Bloms-Funke Petra

  公开号：US20060258741A1

  公开（公告）日：2006-11-16

  Pharmaceutical formulations of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for treating anxiety, anxiety attacks and disorders as well as depression. Related methods of treating anxiety and anxiety attacks or depression are also provided, including methods of administering the active compounds as adjuvants to an antidepressant.

  [2-(3-甲氧基苯基)-环己基甲基]-二甲胺及其代谢物的药物制剂，用于治疗焦虑、焦虑发作和障碍以及抑郁症。还提供了治疗焦虑和焦虑发作或抑郁症的相关方法，包括将活性化合物作为辅助抗抑郁剂的给药方法。
• C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for Therapy of Fibromyalgia
  申请人：Bloms-Funke Petra

  公开号：US20100004341A1

  公开（公告）日：2010-01-07

  Pharmaceutical formulations of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof suitable for treating fibromyalgia or chronic pain due to fibromyalgia, and related methods of treating fibromyalgia or chronic pain due to fibromyalgia are described.

  描述了适用于治疗纤维肌痛或由纤维肌痛引起的慢性疼痛的[2-(3-甲氧基苯基)-环己基甲基]-二甲胺及其代谢物的制剂，以及相关的治疗纤维肌痛或由纤维肌痛引起的慢性疼痛的方法。
• 1-Phenyl-2-DimethylaminomethylCyclohexane Compounds and Therapies for Depressive Symptoms, Pain and Incontinence
  申请人：Friderichs Elmar

  公开号：US20110263699A1

  公开（公告）日：2011-10-27

  Metabolites of [2-(3-methoxyphenyl)-cyclohexylmethyl]dimethylamine as free bases and/or in the form of physiologically acceptable salts, corresponding medicaments, the use of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for producing a medicament used for treating depression, and related methods of treating depression, pain and urinary incontinence.

  [2-(3-甲氧基苯基)环己基甲基]二甲胺的代谢物作为自由碱或以生理可接受的盐的形式，相应的药物，使用[2-(3-甲氧基苯基)环己基甲基]-二甲胺及其代谢物制备用于治疗抑郁症的药物，以及相关的治疗抑郁症、疼痛和尿失禁的方法。
• C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for the Treatment of Anxiety Disorders
  申请人：Bloms-Funke Petra

  公开号：US20100249225A1

  公开（公告）日：2010-09-30

  Pharmaceutical formulations of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for treating anxiety, anxiety attacks and disorders as well as depression. Related methods of treating anxiety and anxiety attacks or depression are also provided, including methods of administering the active compounds as adjuvants to an antidepressant.

  [2-(3-甲氧基苯基)-环己基甲基]-二甲胺及其代谢物的制药配方，用于治疗焦虑、焦虑发作和障碍以及抑郁症。还提供了治疗焦虑和焦虑发作或抑郁症的相关方法，包括将活性化合物作为辅助抗抑郁药物进行给药的方法。