L-Cysteine, L-cysteinyl-L-cysteinyl-L-cysteinyl- | 206058-61-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Cysteine, L-cysteinyl-L-cysteinyl-L-cysteinyl-
• 英文别名: (2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoic acid
• CAS: 206058-61-9
• 化学式: C₁₂H₂₂N₄O₅S₄
• 分子量: 430.6
• InChiKey: DFUGWFWOVGOLQR-XAMCCFCMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  155
• 氢给体数：
  9
• 氢受体数：
  10

文献信息

• Antifungal compositions
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20040018983A1

  公开（公告）日：2004-01-29

  Methods for elucidating an antifungal or anti-yeast compound which selectively bind to a fungal or yeast zinc finger-containing protein within a fungus are disclosed. Assays of screening for compounds that are effective for binding to a fungal or yeast zinc finger-containing protein are also provided. It is also provided a pharmaceutical composition containing an effective amount of a compound or compounds identified as effective for binding to or associating with a fungal or yeast zinc finger-containing protein using the disclosed methods. Fungal and/or yeast infections can be treated or prevented by administering to a patient in need of treatment the pharmaceutical composition containing an effective amount of an compound or compounds identified as effective for binding to or associating with a fungal or yeast zinc finger-containing protein using the disclosed methods.

  本发明公开了用于阐明抗真菌或抗酵母菌化合物的方法，这些化合物可选择性地与真菌或酵母菌中的含锌指蛋白结合。还提供了筛选有效结合真菌或酵母含锌指蛋白的化合物的检测方法。还提供了一种药物组合物，其中含有有效量的一种或多种化合物，利用所公开的方法，这些化合物被鉴定为能有效地与真菌或酵母的含锌指蛋白结合或结合。通过向需要治疗的患者施用含有有效量的化合物的药物组合物，可以治疗或预防真菌和/或酵母菌感染。
• COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS
  申请人：Diadexus, Inc.

  公开号：EP1432824A2

  公开（公告）日：2004-06-30
• COMPOSITIONS AND METHODS RELATING TO OVARY SPECIFIC GENES AND PROTEINS
  申请人：Diadexus, Inc.

  公开号：EP1432804A2

  公开（公告）日：2004-06-30
• COMPOSITIONS AND METHODS RELATING TO ENDOMETRIAL SPECIFIC GENES AND PROTEINS
  申请人：Diadexus, Inc.

  公开号：EP1465906A1

  公开（公告）日：2004-10-13
• COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO OVARIAN SPECIFIC GENES AND PROTEINS
  申请人：Diadexus, Inc.

  公开号：EP1581641A2

  公开（公告）日：2005-10-05