2-acetamido-2-(2-hydroxyphenyl)acetic Acid | 68802-33-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-acetamido-2-(2-hydroxyphenyl)acetic Acid
• CAS: 68802-33-5
• 化学式: C₁₀H₁₁NO₄
• 分子量: 209.2
• InChiKey: CMSFPXXGASWVLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
  申请人：BioCryst Pharmaceuticals, Inc.

  公开号：US11021458B2

  公开（公告）日：2021-06-01

  Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

  公开了式 I 和 II 的化合物及其药学上可接受的盐和原药，它们是补体系统的抑制剂。还提供了包含此类化合物的药物组合物，以及使用这些化合物和组合物治疗或预防以补体系统活性异常为特征的疾病或病症的方法。
• Compositions comprising phenyl-glycine derivatives
  申请人：——

  公开号：US20030108496A1

  公开（公告）日：2003-06-12

  The invention relates to compositions and methods useful for treating a variety of cosmetic conditions and dermatological disorders, where the composition includes a phenyl glycine derivative represented by the following formula: 1 wherein, R 1 and R 2 are independently H, I, F, Cl, Br, OH, SH, NH 2 , NHNH 2 , alkyl, aralkyl, alkoxy, acetoxy, acyloxy group having 1 to 9 carbon atoms, and being attached at the 2, 3 or 4 position of the phenyl group, whereby when R 1 and/or R 2 are OH, SH, NH 2 , they may be acetylated or acylated with 1 to 9 carbon atoms; R 3 is H, formyl, acetyl, propanoyl, acyl, alkyl, aralkyl or an aryl group having 1 to 9 carbon atoms; R 4 is OH, NH 2 , NHOH, NHNH 2 , or OR; where R is an alkyl, aralkyl or aryl group having 1 to 9 carbon atoms; the H attached to any carbon or nitrogen atom may be substituted by I, F, Cl, Br, OH, SH, NH 2 , NHNH 2 , an alkyl, aralkyl, alkoxy or acyl group having 1 to 9 carbon atoms. Phenyl-glycine and its derivatives may be present as isomeric D or L, non-isomeric or racemic DL, as a free acid, salt, lactone, amide or ester form.

  本发明涉及用于治疗各种美容病症和皮肤病的组合物和方法，其中组合物包括由下式表示的苯基甘氨酸衍生物： 1 其中，R 1 和 R 2 独立地为 H、I、F、Cl、Br、OH、SH、NH 2 、NHNH 2 烷基、芳烷基、烷氧基、乙酰氧基、具有 1 至 9 个碳原子的酰氧基，且连接在苯基的 2、3 或 4 位，其中当 R 1 和/或 R 2 是 OH、SH、NH 2 它们可以是乙酰化的，也可以是带有 1 至 9 个碳原子的酰化的；R 3 是 H、甲酰基、乙酰基、丙酰基、酰基、烷基、芳基或具有 1 至 9 个碳原子的芳基；R 4 是 OH、NH 2 、NHOH、NHNH 2 或 OR；其中 R 是具有 1 至 9 个碳原子的烷基、芳基或芳基；与任何碳原子或氮原子相连的 H 可被 I、F、Cl、Br、OH、SH、NH 2 、NHNH 2 1 至 9 个碳原子的烷基、芳基、烷氧基或酰基取代。苯基甘氨酸及其衍生物可以 D 或 L、非同分异构体或外消旋 DL、游离酸、盐、内酯、酰胺或酯的形式存在。
• COMPOSITIONS COMPRISING PHENYL-GLYCINE DERIVATIVES
  申请人：Yu, Ruey J., Dr.

  公开号：EP1455734A1

  公开（公告）日：2004-09-15
• SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS
  申请人：Biocryst Pharmaceuticals, Inc.

  公开号：EP3687506A1

  公开（公告）日：2020-08-05
• US6824786B2
  申请人：——

  公开号：US6824786B2

  公开（公告）日：2004-11-30