(2S,4S)-1-((R)-2-amino-3-methyl-3-(3-phenylpropylsulfonyl)butanoyl)-4-fluoropyrrolidine-2-carbonitrile | 483367-77-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4S)-1-((R)-2-amino-3-methyl-3-(3-phenylpropylsulfonyl)butanoyl)-4-fluoropyrrolidine-2-carbonitrile
• 英文别名: (2S,4S)-1-[(2R)-2-amino-3-methyl-3-(3-phenylpropylsulfonyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile
• CAS: 483367-77-7
• 化学式: C₁₉H₂₆FN₃O₃S
• 分子量: 395.5
• InChiKey: KUZMXTVZAIDNLE-YESZJQIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Fluoropyrrolidines as dipeptidyl peptidase inhibitors
  申请人：——

  公开号：US20040171848A1

  公开（公告）日：2004-09-02

  The present invention relates to novel compounds, their use for inhibiting serine proteases, such as dipeptidyl peptidases, such as dipeptidyl peptidase IV (DPP-IV) and to methods for their production and their therapeutic utility.

  本发明涉及新型化合物，其用于抑制丝氨酸蛋白酶，例如二肽基肽酶，例如二肽基肽酶IV（DPP-IV），以及其生产方法和治疗效用。
• FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1406873A2

  公开（公告）日：2004-04-14
• US7132443B2
  申请人：——

  公开号：US7132443B2

  公开（公告）日：2006-11-07
• [EN] FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS<br/>[FR] FLUOROPYRROLIDINES INHIBITRICES DE LA DIPEPTIDYL PEPTIDASE
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2003002531A2

  公开（公告）日：2003-01-09

  The present invention relates to novel compounds of formula (I): , their use for inhibiting serine proteases, such as dipeptidyl peptidases, such as dipeptidyl peptidase IV (DPP-IV) and to methods for their production and their therapeutic utility.