2-[(1-Benzylpyridin-1-ium-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;chloride | 388115-12-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-[(1-Benzylpyridin-1-ium-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;chloride
• CAS: 388115-12-6
• 化学式: C24H24ClNO3
• 分子量: 409.9
• InChiKey: IPXOZZPXNCBASH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.64
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts
  申请人：——

  公开号：US20030069289A1

  公开（公告）日：2003-04-10

  The present invention provides an excellent acetylcholinesterase inhibitor. That is, it provides an acetylcholinesterase inhibitor comprising a 1-benzylpyridinium salt represented by the following formula: 1 wherein R 1 , R 2 , R 3 and R 4 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a nitrile group, a C 1-6 alkyl group, a C 1-6 alkoxy group etc.; R 5 represents a hydrogen atom, a halogen atom etc.; the partial structure: 2 is a group represented by the formula >C(R 6 )—CH 2 — (wherein R 6 is a hydrogen atom or a halogen atom) or >C═CH—; X−represents a halide ion or organic sulfonic acid ion; and m is 0 or an integer from 1 to 5.

  本发明提供了一种优良的乙酰胆碱酯酶抑制剂。即，提供一种由下式表示的1-苄基吡啶盐组成的乙酰胆碱酯酶抑制剂：1其中R1、R2、R3和R4相同或不同，分别表示氢原子、卤素原子、羟基、腈基、C1-6烷基、C1-6烷氧基等；R5表示氢原子、卤素原子等；部分结构：2是由公式>C(R6)-CH2-（其中R6是氢原子或卤素原子）或>C═CH-表示的基团；X-表示卤离子或有机磺酸离子；m为0或1至5的整数。
• ACETYLCHOLINESTERASE INHIBITORS CONTAINING 1-BENZYL- PYRIDINIUM SALTS
  申请人：Eisai Co., Ltd.

  公开号：EP1285656A1

  公开（公告）日：2003-02-26

  The present invention provides an excellent acetylcholinesterase inhibitor. That is, it provides an acetylcholinesterase inhibitor comprising a 1-benzylpyridinium salt represented by the following formula: wherein R1, R2, R3 and R4 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a nitrile group, a C1-6 alkyl group, a C1-6 alkoxy group etc.; R5 represents a hydrogen atom, a halogen atom etc.; the partial structure: is a group represented by the formula >C(R6)-CH2- (wherein R6 is a hydrogen atom or a halogen atom) or >C=CH-; X- represents a halide ion or organic sulfonic acid ion; and m is 0 or an integer from 1 to 5.

  本发明提供了一种优良的乙酰胆碱酯酶抑制剂。 其中 R1、R2、R3 和 R4 相互相同或不同，各自代表氢原子、卤素原子、羟基、腈基、C1-6 烷基、C1-6 烷氧基等；R5 代表氢原子、卤素原子等。 部分结构：是由式 >C(R6)-CH2-（其中 R6 是氢原子或卤素原子）或 >C=CH- 所代表的基团；X- 代表卤离子或有机磺酸离子；以及 m 是 0 或 1 至 5 的整数。
• Methods and compositions for improving cognitive function
  申请人：AgeneBio, Inc.

  公开号：US11160785B2

  公开（公告）日：2021-11-02

  The invention relates to compositions comprising a synaptic vesicle glycoprotein 2A (SV2A) inhibitor in an extended release and an acetylcholinesterase inhibitor (AChEIs). The invention also relates to using such compositions in treating cognitive impairment associated with central nervous system disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), dementia, Alzheimer's Disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis (ALS), cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease (PD), autism, compulsive behavior, and substance addiction.

  本发明涉及一种组合物，该组合物包含一种缓释的突触小泡糖蛋白 2A (SV2A) 抑制剂和一种乙酰胆碱酯酶抑制剂 (AChEIs)。本发明还涉及使用此类组合物治疗有需要或有风险的受试者与中枢神经系统疾病相关的认知障碍，包括但不限于具有或有风险的受试者与年龄相关的认知障碍、轻度认知障碍（MCI）、痴呆症、阿尔茨海默氏症（Alzheimer）、老年痴呆症（Dementia）、阿尔茨海默氏症（Alzheimer）等、痴呆症、阿尔茨海默病 (AD)、前驱 AD、创伤后应激障碍 (PTSD)、精神分裂症、双相情感障碍、肌萎缩性脊髓侧索硬化症 (ALS)、癌症治疗相关认知障碍、智力迟钝、帕金森病 (PD)、自闭症、强迫行为和药物成瘾。
• PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVES
  申请人：Eisai Co., Ltd.

  公开号：EP1047674B1

  公开（公告）日：2005-03-30
• METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
  申请人：The Johns Hopkins University

  公开号：EP2533645A1

  公开（公告）日：2012-12-19