2-Chloro-5-(3-nitrophenyl)pyridine | 163563-09-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Chloro-5-(3-nitrophenyl)pyridine
• CAS: 163563-09-5
• 化学式: C₁₁H₇ClN₂O₂
• 分子量: 234.642
• InChiKey: CFJONZPCZDQKCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Chloro-5-(3-nitrophenyl)pyridine 在 镍 氢气 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以89%的产率得到3-(6-chloro-pyridin-3-yl)phenylamine
  参考文献：
  名称：

  WO2006/71940

  摘要：

  公开号：
• 作为产物：
  描述：

  (2Z,4E)-2-Cyano-5-dimethylamino-4-(3-nitro-phenyl)-penta-2,4-dienoic acid tert-butyl ester 在 盐酸 、 溶剂黄146 作用下， 反应 18.0h， 以55%的产率得到2-Chloro-5-(3-nitrophenyl)pyridine
  参考文献：
  名称：

  New Synthetic Routes to 3-, 5-, and 6-Aryl-2-chloropyridines

  摘要：

  The efficient synthesis of 3-, 5-, and 6-aryl-2-chloropyridines via the facile preparation of 5-(dimethyamino)aryl-substituted pentadienyl nitriles and cyclization with hydro chloric acid is described. This approach allows for the introduction of other electron-withdrawing substituents on the pyridine ring as well as the preparation of the desired unsubstituted arylpyridines. Some differences in the rates of cyclization of the pentadienyl nitriles as well as the yields of chloropyridines were observed that depended on the position and degree of substitution in the aryl substituent. The arylpentadienyl nitriles 5 and 6 could also be converted directly into the corresponding 2-aminopyridines.

  DOI：

  10.1021/jo00117a029

文献信息

• Enzyme modulators and treatments
  申请人：Flynn L. Daniel

  公开号：US20070078121A1

  公开（公告）日：2007-04-05

  Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, immunological disorders, hyperproliferative diseases, cancer, and diseases characterized by hyper-vascularization are provided. In a preferred embodiment, modulation of the activation state of kinases, including p38 kinase protein, abl kinase protein, bcr-abl kinase protein, braf kinase protein, VEGFR kinase protein, or PDGFR kinase protein, comprises the step of contacting said kinase protein with the novel compounds.

  提供了新型化合物及其使用方法，用于治疗炎症性疾病、免疫性疾病、过度增生性疾病、癌症以及以高血管化为特征的疾病。在一种优选实施方式中，调节激酶的激活状态，包括p38激酶蛋白、abl激酶蛋白、bcr-abl激酶蛋白、braf激酶蛋白、VEGFR激酶蛋白或PDGFR激酶蛋白，包括将该激酶蛋白与新型化合物接触的步骤。
• ENZYME MODULATORS AND TREATMENTS
  申请人：Flynn L. Daniel

  公开号：US20080113967A1

  公开（公告）日：2008-05-15

  Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, hyperproliferative diseases, cancer, and diseases characterized by hyper-vascularization are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein, abl kinase protein, ber-abl kinase protein, braf kinase protein, VEGFR kinase protein, or PDGFR kinase protein comprises the step of contacting said kinase protein with the novel compounds.

  本发明提供了新的化合物及其使用方法，用于治疗炎症状况、过度增殖性疾病、癌症和以高血管化为特征的疾病。在优选实施例中，调节p38激酶蛋白、abl激酶蛋白、ber-abl激酶蛋白、braf激酶蛋白、VEGFR激酶蛋白或PDGFR激酶蛋白的激活状态，包括将该激酶蛋白与新的化合物接触的步骤。
• Substituted 3-alkyl-6-phenyl-1,2,4-triazolo(4,3-a)pyridines, processes for their preparation and pharmaceutical compositions containing them
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0017438A1

  公开（公告）日：1980-10-15

  There are provided novel 3-alkyl-6-(substituted-phenyl)-1,2,4-triazolo[4,3-a]pyridines useful as anxiolytic agents, processes for their preparation and pharmaceutical compositions containing them. The compounds have the formula: wherein R, is hydrogen, alkyl (C1-C4), alkoxy (C,-C4), fluoro, chloro, bromo, trifluoromethyl, cyano, carboxy, alkoxycarbonyl (C2-C5), carboxamido, nitro, amino, acylamino (C1-C4), monoalkylamino (C1-C4) or dialkylamino wherein each alkyl group has up to 4 carbon atoms and R2 is alkyl (C1-C3); or a pharmacologically acceptable acid-addition salt thereof.

  本发明提供了可用作抗焦虑剂的新型 3-烷基-6-（取代苯基）-1,2,4-三唑并[4,3-a]吡啶、其制备工艺以及含有这些化合物的药物组合物。这些化合物的化学式如下 其中 R，是氢、烷基（C1-C4）、烷氧基（C,-C4）、氟、氯、溴、三氟甲基、氰基、羧基、烷氧羰基（C2-C5）、羧酰胺基、硝基、氨基、酰氨基（C1-C4）、单烷基氨基（C1-C4）或二烷基氨基，其中每个烷基最多有 4 个碳原子，R2 是烷基（C1-C3）；或其药理学上可接受的酸加成盐。
• US4209626A
  申请人：——

  公开号：US4209626A

  公开（公告）日：1980-06-24
• US4242515A
  申请人：——

  公开号：US4242515A

  公开（公告）日：1980-12-30