2-(4-Chloro-2-pyridinyl)-1-(4-fluorophenyl)ethanone oxime | 437384-25-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Chloro-2-pyridinyl)-1-(4-fluorophenyl)ethanone oxime
• 英文别名: N-[2-(4-chloropyridin-2-yl)-1-(4-fluorophenyl)ethylidene]hydroxylamine
• CAS: 437384-25-3
• 化学式: C₁₃H₁₀ClFN₂O
• 分子量: 264.687
• InChiKey: WLLWVJWWLGVEEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-Chloro-2-pyridinyl)-1-(4-fluorophenyl)ethanone oxime 、 三氟乙酸酐 在 三乙胺 作用下， 以 乙二醇二甲醚 为溶剂， 生成
  参考文献：
  名称：

  Pyrazolopyridines with potent activity against herpesviruses: Effects of C5 substituents on antiviral activity

  摘要：

  Synthesis of a series of 5-substituted as well as 5,7-disubstituted 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-phenylpyrazolo [1,5-a]pyridin-7-amines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar to or better than acyclovir are described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.120
• 作为产物：
  描述：

  2-(4-Chloro-2-pyridinyl)-1-(4-fluorophenyl)ethanone 在 sodium hydroxide 、 盐酸羟胺 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以84%的产率得到2-(4-Chloro-2-pyridinyl)-1-(4-fluorophenyl)ethanone oxime
  参考文献：
  名称：

  Pyrazolopyridines with potent activity against herpesviruses: Effects of C5 substituents on antiviral activity

  摘要：

  Synthesis of a series of 5-substituted as well as 5,7-disubstituted 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-phenylpyrazolo [1,5-a]pyridin-7-amines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar to or better than acyclovir are described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.120

文献信息

• Therapeutic compounds
  申请人：——

  公开号：US20040072853A1

  公开（公告）日：2004-04-15

  The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. 1

  本发明提供式(I)的化合物：其中所有变量如本文所定义，包含它们的药物组合物、制备它们的过程以及它们作为药物剂的用途。1
• Pyrazolo-pyridines for the treatment of herpes infections
  申请人：——

  公开号：US20040214834A1

  公开（公告）日：2004-10-28

  The present invention provides compounds of formula (I): 1 wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供公式（I）的化合物：1其中所有变量的定义如此，包含它们的制药组合物，制备它们的过程以及它们作为制药剂的用途。
• Use of pyrazolopyridines as therapeutic compounds
  申请人：Boyd F Leslie

  公开号：US20050107400A1

  公开（公告）日：2005-05-19

  The present invention provides methods for the treatment or prophylaxis of viral infections such as herpes viral infections.

  本发明提供了治疗或预防病毒感染，例如疱疹病毒感染的方法。
• Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds
  申请人：Gudmundsson Kristjan

  公开号：US20050192295A1

  公开（公告）日：2005-09-01

  The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了公式（I）的化合物：其中所有变量如本文所定义，包含该化合物的制药组合物，制备该化合物的过程以及它们作为制药剂的用途。
• Pyrazolopyridines, process for their preparation and use as therapeutic compounds
  申请人：Alberti John Michael

  公开号：US20060058319A1

  公开（公告）日：2006-03-16

  The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了式(I)的化合物：其中所有变量如本文所定义，包含这些化合物的制药组合物，制备这些化合物的过程以及它们作为制药剂的用途。