Bis(desenex) ZINC

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Bis(desenex) ZINC
• 英文别名: undec-10-enoic acid;zinc
• 化学式: C22H40O4Zn
• 分子量: 433.9
• InChiKey: RBLUZDDDFHCLDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.75
• 重原子数：
  27
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PREVENTIVES/REMEDIES FOR SKIN DISEASES
  申请人：Showa Denko Kabushiki Kaisha

  公开号：EP1077066A1

  公开（公告）日：2001-02-21

  The present invention relates to an agent for preventing and treating skin diseases comprising an ascorbic acid derivative, a composition containing the agent and a preparation containing the agent, each of which has an effect of preventing and/or treating skin diseases and is employable in various forms such as a medical product, a quasi-drug and a cosmetic material. An object of the present invention is to provide an agent, which causes neither irritation nor other side effects and is capable of effectively preventing and/or treating skin diseases, and a composition containing the agent. The agent for preventing and treating skin diseases according to the present invention comprises as an active ingredient an ascorbic acid derivative which is a compound represented by the following formula (1) or a salt thereof and which per se exhibits no anti-oxidation activity but is capable of transforming in vivo into a compound having an anti-oxidation activity; wherein R1 represents a group capable of bonding to the carbon at the 2-position of the ascorbic acid skeleton through an ether or ester bond and transformable in vivo into a hydroxyl group, and R2 to R4 may be the same or different and each represents a hydroxyl group or a group derived therefrom.

  本发明涉及一种预防和治疗皮肤病的药剂，包括一种抗坏血酸衍生物、一种含有该药剂的组合物和一种含有该药剂的制剂，每种药剂都具有预防和/或治疗皮肤病的效果，并可用于各种形式，如医疗产品、准药品和化妆品材料。本发明的目的是提供一种既不会产生刺激也不会产生其他副作用、能够有效预防和/或治疗皮肤病的制剂，以及一种含有该制剂的组合物。 根据本发明，预防和治疗皮肤病的制剂包括作为活性成分的抗坏血酸衍生物，抗坏血酸衍生物是由下式（1）表示的化合物或其盐，其本身不具有抗氧化活性，但能在体内转化为具有抗氧化活性的化合物； 其中 R1 代表能通过醚键或酯键与抗坏血酸骨架 2 位碳结合并能在体内转化为羟基的基团，R2 至 R4 可以相同或不同，且各代表一个羟基或由其衍生的基团。
• Acne treatment compositions and methods of use
  申请人：Majewski P. George

  公开号：US20080070875A1

  公开（公告）日：2008-03-20

  The present invention relates to a composition for treating acne comprising an antimicrobial/anti-inflammatory polyphenolic molecule(s) including quercetin and rosmarinic acid in combination with salicyclic acid and/or salicylate salts in a topical and/or cosmetic delivery vehicle. The invention further relates to a method for treating acne by topically administering one of the compositions in an amount therapeutically effective to reduce the redness and blemishes associated with acne.
• US6437002B1
  申请人：——

  公开号：US6437002B1

  公开（公告）日：2002-08-20