(2R)-2-azaniumyl-4-(2-chlorophenyl)butanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-azaniumyl-4-(2-chlorophenyl)butanoate
• 化学式: C10H12ClNO2
• 分子量: 213.66
• InChiKey: ZYQDUOLAVXZHAL-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• POTENT AND SELECTIVE INHIBITORS OF NAV1.7
  申请人：AMGEN INC

  公开号：US20160024159A1

  公开（公告）日：2016-01-28

  Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted Na V 1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of Na V 1.7. Other embodiments are conjugated embodiments of the inventive composition of matter and pharmaceutical compositions containing the inventive composition of matter. Isolated nucleic acids encoding some embodiments of inventive polypeptides and expression vectors, and recombinant host cells containing them are disclosed. A method of treating or preventing pain is also disclosed.

  本文揭示了一种物质组合物，包括一种孤立的多肽，该多肽是一种外周限制的NaV1.7抑制剂。在一些公开的实施方式中，这种孤立的多肽是NaV1.7的抑制剂。其他实施方式是该物质组合物的共轭实施方式和含有该物质组合物的药物组合物。还揭示了编码一些创新多肽的孤立核酸和表达载体以及含有它们的重组宿主细胞。还揭示了一种治疗或预防疼痛的方法。
• Potent and selective inhibitors of Nav1.7
  申请人：AMGEN INC.

  公开号：US10344060B2

  公开（公告）日：2019-07-09

  Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted NaV1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of NaV1.7. Other embodiments are conjugated embodiments of the inventive composition of matter and pharmaceutical compositions containing the inventive composition of matter. Isolated nucleic acids encoding some embodiments of inventive polypeptides and expression vectors, and recombinant host cells containing them are disclosed. A method of treating or preventing pain is also disclosed.

  公开了一种物质组合物，其中包含一种分离多肽，它是一种外周限制性 NaV1.7 抑制剂。在一些已公开的实施方案中，分离的多肽是 NaV1.7 的抑制剂。其他实施方案是本发明物质组合物和含有本发明物质组合物的药物组合物的共轭实施方案。本发明公开了编码本发明多肽的某些实施方案的分离核酸和表达载体，以及含有它们的重组宿主细胞。还公开了一种治疗或预防疼痛的方法。
• POTENT AND SELECTIVE INHIBITORS OF Nav1.7
  申请人：Amgen Inc.

  公开号：EP2970408A2

  公开（公告）日：2016-01-20
• [EN] POTENT AND SELECTIVE INHIBITORS OF Nav1.7<br/>[FR] INHIBITEURS SÉLECTIFS ET PUISSANTS DE NAV1.7
  申请人：AMGEN INC

  公开号：WO2014165277A2

  公开（公告）日：2014-10-09

  Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted Nav1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of Nav1.7. Other embodiments are conjugated embodiments of the inventive composition of matter and pharmaceutical compositions containing the inventive composition of matter. Isolated nucleic acids encoding some embodiments of inventive polypeptides and expression vectors, and recombinant host cells containing them are disclosed. A method of treating or preventing pain is also disclosed.