1-Tert-butyl 2-methyl (2S)-2-methyl-4-oxopyrrolidine-1,2-dicarboxylate | 144527-35-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Tert-butyl 2-methyl (2S)-2-methyl-4-oxopyrrolidine-1,2-dicarboxylate
• 英文别名: 1-O-tert-butyl 2-O-methyl (2S)-2-methyl-4-oxopyrrolidine-1,2-dicarboxylate
• CAS: 144527-35-5
• 化学式: C₁₂H₁₉NO₅
• 分子量: 257.28
• InChiKey: JKSLNLOQSHITFJ-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS
  申请人：NOVARTIS AG

  公开号：US20170369473A1

  公开（公告）日：2017-12-28

  The invention relates to heterocyclic angiotensin II type 2 (AT 2 ) receptor antagonists of formula (I), and pharmaceutically acceptable salts thereof, ((I) in which all of the variables are as defined in the specification, pharmaceutical compositions thereof,combinations thereof, and their use as medic-aments, particularly for the treatment of neuropathic or inflammatory pain.
• [EN] PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS<br/>[FR] DÉRIVÉS DE PYRROLIDINE COMME ANTAGONISTES DES RÉCEPTEURS DE TYPE 2 DE L'ANGIOTENSINE II
  申请人：NOVARTIS AG

  公开号：WO2016113668A1

  公开（公告）日：2016-07-21

  The invention relates to heterocyclic angiotensin II type 2 (AT2) receptor antagonists of formula (I), and pharmaceutically acceptable salts thereof, ((I) in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of neuropathic or inflammatory pain.