Tert-butyl 2-azaspiro[3.3]hept-6-ylcarbamate oxalate | 1400764-62-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tert-butyl 2-azaspiro[3.3]hept-6-ylcarbamate oxalate
• 英文别名: tert-butyl N-(2-azaspiro[3.3]heptan-6-yl)carbamate;oxalic acid
• CAS: 1400764-62-6
• 化学式: 0C₂H₂O₄*C₁₁H₂₀N₂O₂
• 分子量: 257.31
• InChiKey: NUEDJSDOGUZUCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.42
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine 、 Tert-butyl 2-azaspiro[3.3]hept-6-ylcarbamate oxalate 在 N,N-二异丙基乙胺 作用下， 以 正丁醇 为溶剂， 以57 %的产率得到tert-butyl (2-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)-2-azaspiro [3.3] heptan-6-yl)carbamate
  参考文献：
  名称：

  [EN] MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN
  [FR] MODULATEURS DE LA PROTÉINE PROTO-ONCOGÈNE DE LA FAMILLE MYC

  摘要：

  Disclosed herein are compounds and compositions having potency in the modulation of Myc family proteins. Such compounds and compositions can be used in the treatment of proliferative diseases, such as cancer, or in the treatment of disease where modulation of Myc family proteins is desired. Also disclosed herein are methods of using said compounds and compositions.

  公开号：

  WO2023163712A1

文献信息

• [EN] MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN<br/>[FR] MODULATEURS DE LA PROTÉINE PROTO-ONCOGÈNE DE LA FAMILLE MYC
  申请人：[en]NALO THERAPEUTICS

  公开号：WO2023163712A1

  公开（公告）日：2023-08-31

  Disclosed herein are compounds and compositions having potency in the modulation of Myc family proteins. Such compounds and compositions can be used in the treatment of proliferative diseases, such as cancer, or in the treatment of disease where modulation of Myc family proteins is desired. Also disclosed herein are methods of using said compounds and compositions.