1-Ethyl-3-[(2-methoxyphenyl)methyl]urea | 71475-37-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Ethyl-3-[(2-methoxyphenyl)methyl]urea
• CAS: 71475-37-1
• 化学式: C₁₁H₁₆N₂O₂
• mdl: MFCD17588433
• 分子量: 208.26
• InChiKey: IDSARRMSQGJLFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻甲氧基苄胺 、 异氰酸乙酯 以 二氯甲烷 为溶剂， 反应 2.0h， 以92%的产率得到1-Ethyl-3-[(2-methoxyphenyl)methyl]urea
  参考文献：
  名称：

  Synthesis and activity on rat aorta rings and rat pancreatic β-cells of ring-opened analogues of benzopyran-type potassium channel activators

  摘要：

  Ring-opened analogues of dihydrobenzopyran potassium channel openers (PCOs) were prepared and evaluated as putative PCOs on rat aorta rings (myorelaxant effect) and rat pancreatic beta-cells (inhibition of insulin secretion). These derivatives are characterized by the presence of a sulfonylurea, a urea or an amide function. Some compounds bearing an arylurea moiety provoked vasorelaxant effects and a marked inhibition of insulin release. Derivatives bearing a sulfonylurea or an amide function were, however, poorly active on both tissues. Structure-activity relationships and apparent tissue selectivity are discussed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.04.043

文献信息

• Synthesis and activity on rat aorta rings and rat pancreatic β-cells of ring-opened analogues of benzopyran-type potassium channel activators
  作者：Smail Khelili、Xavier Florence、Mourad Bouhadja、Samia Abdelaziz、Nadia Mechouch、Yekhlef Mohamed、Pascal de Tullio、Philippe Lebrun、Bernard Pirotte

  DOI：10.1016/j.bmc.2008.04.043

  日期：2008.6

  Ring-opened analogues of dihydrobenzopyran potassium channel openers (PCOs) were prepared and evaluated as putative PCOs on rat aorta rings (myorelaxant effect) and rat pancreatic beta-cells (inhibition of insulin secretion). These derivatives are characterized by the presence of a sulfonylurea, a urea or an amide function. Some compounds bearing an arylurea moiety provoked vasorelaxant effects and a marked inhibition of insulin release. Derivatives bearing a sulfonylurea or an amide function were, however, poorly active on both tissues. Structure-activity relationships and apparent tissue selectivity are discussed. (C) 2008 Elsevier Ltd. All rights reserved.