3-[三(羟甲基)磷基]丙酸酯 | 15931-64-3

• 分子结构分类: 有机化合物 - 有机磷化合物 - 四烷基鏻化合物
• 中文名称: 3-[三(羟甲基)磷基]丙酸酯
• 中文别名: 3-(三[羟基甲基]膦)丙酸
• 英文名称: 3-Trishydroxymethylphosphonio-propionsaeure-betain
• 英文别名: β-(tris-(hydroxymethyl)phosphino)propionic acid；3-[Tris(hydroxymethyl)phosphonio]propionate；3-[tris(hydroxymethyl)phosphaniumyl]propanoate
• CAS: 15931-64-3
• 化学式: C₆H₁₃O₅P
• 分子量: 196.14
• InChiKey: AWJWHBODZRSWCK-UHFFFAOYSA-N

物化性质

• 熔点：
  147-148 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R37
• 海关编码：
  2931900090

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 3-phosphino-propionic acid 生成 3-[三(羟甲基)磷基]丙酸酯
  参考文献：
  名称：

  Issleib,K.; Kuemmel,R., Zeitschrift fur Chemie, 1967, vol. 7, # 6, p. 235

  摘要：

  DOI：

文献信息

• SUBSTANCE-CONTAINING VESICLE, AND PRODUCTION METHOD THEREFOR
  申请人：Japan Science and Technology Agency

  公开号：EP2962752A1

  公开（公告）日：2016-01-06

  Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.

  本发明提供了一种含物质囊泡的单分散团聚体，其中填充的物质浓度高于常规浓度。将目标物质包含在水介质中的混合溶液与交联囊泡的单分散团聚体混合，交联囊泡由规定聚合物组成，其中包括第一聚合物，即具有不带电亲水段和第一带电段的嵌段共聚物，以及具有与第一带电段电荷相反的第二带电段的第二聚合物，第一聚合物和/或第二聚合物在其中交联。因此，交联囊泡中含有目标物质。
• Substance-containing vesicle, and production method therefor
  申请人：JAPAN SCIENCE AND TECHNOLOGY AGENCY

  公开号：US10322092B2

  公开（公告）日：2019-06-18

  Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.

  本发明提供了一种含物质囊泡的单分散团聚体，其中填充的物质浓度高于常规浓度。将目标物质包含在水介质中的混合溶液与交联囊泡的单分散团聚体混合，交联囊泡由规定聚合物组成，其中包括第一聚合物，即具有不带电亲水段和第一带电段的嵌段共聚物，以及具有与第一带电段电荷相反的第二带电段的第二聚合物，第一聚合物和/或第二聚合物在其中交联。因此，交联囊泡中含有目标物质。
• CD44 BINDING PEPTIDES
  申请人：Exchange Imaging Technologies GmbH

  公开号：EP3086802A1

  公开（公告）日：2016-11-02
• US9782358B2
  申请人：——

  公开号：US9782358B2

  公开（公告）日：2017-10-10
• [EN] CD44 BINDING PEPTIDES<br/>[FR] PEPTIDES SE LIANT À CD44
  申请人：EXCHANGE IMAGING TECHNOLOGIES GMBH

  公开号：WO2015097170A1

  公开（公告）日：2015-07-02

  The present invention relates to a protein which binds to the domain encoded by exon 9 of human CD44 (CD44ex9), to fusion proteins and conjugates of said protein and especially to nanoparticles conjugated to said protein. The invention further relates to a method of production for the protein and the respective conjugated nanoparticles and the use of the protein of the invention for treatment and diagnosis of cancer diseases.