2-Amino-5,5-dimethyl-4-oxohexanoic acid | 1423116-94-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-5,5-dimethyl-4-oxohexanoic acid
• 英文别名: 2-amino-5,5-dimethyl-4-oxohexanoic acid
• CAS: 1423116-94-2
• 化学式: C₈H₁₅NO₃
• mdl: MFCD24115744
• 分子量: 173.21
• InChiKey: CUZGPBLINPRZQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Azaindoline compounds as granzyme B inhibitors
  申请人：viDA Therapeutics Inc.

  公开号：US10246487B2

  公开（公告）日：2019-04-02

  Azaindoline compounds as granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous scleroderma, epidermolysis bullosa, radiation dermatitis, alopecia areata, and discoid lupus erythematosus are provided.

  作为颗粒酶 B 抑制剂的氮杂吲哚啉化合物、包括这些化合物的组合物以及使用这些化合物的方法。提供了治疗皮肤硬皮病、表皮松解症、放射性皮炎、斑秃和盘状红斑狼疮的方法。
• Anti-Fibrogenic Compounds, Methods and Uses Thereof
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：US20160120857A1

  公开（公告）日：2016-05-05

  Presented herein are methods for treatment of diseases or conditions related to fibrosis. Compounds, or pharmaceutically acceptable salts thereof or pharmaceutical compositions thereof provide for the treatment of diseases or conditions related to fibrosis. The methods utilize the compounds kynurenine, kynurenic acid and xanthurenic acid, and various analogues, related structures and pharmaceutical compositions thereof, wherein the compounds are represented by one or more compounds represented by Formulas I, II, or II as set out below:
• PYRROLE COMPOUNDS AS GRANZYME B INHIBITORS
  申请人：viDA Therapeutics Inc.

  公开号：US20170015705A1

  公开（公告）日：2017-01-19

  Pyrrole compounds as Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Method for treating cutaneous scleroderma, epidermolysis bullosa, radiation dermatitis, alopecia areata, and discoid lupus erythematosus are provided.
• PROLINE COMPOUNDS AS GRANZYME B INHIBITORS
  申请人：viDA Therapeutics Inc.

  公开号：US20170015706A1

  公开（公告）日：2017-01-19

  Proline compounds as Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous scleroderma, epidermolysis bullosa, radiation dermatitis, alopecia areata, and discoid lupus erythematosus are provided.
• COVALENT GRANZYME B INHIBITORS
  申请人：viDA Therapeutics Inc.

  公开号：US20170015707A1

  公开（公告）日：2017-01-19

  Covalent Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. A method for treating cutaneous scleroderma, epidermolysis bullosa, radiation dermatitis, alopecia areata, and discoid lupus erythematosus are provided.