3-[苄基(乙基)氨基]-1,2-丙烷二醇 | 85721-31-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-[苄基(乙基)氨基]-1,2-丙烷二醇
• 英文名称: 3-[benzyl(ethyl)amino]propane-1,2-diol
• 英文别名: 3-(N-Benzyl-N-ethylamino)propane-1,2-diol
• CAS: 85721-31-9
• 化学式: C₁₂H₁₉NO₂
• mdl: MFCD19316580
• 分子量: 209.288
• InChiKey: BITYXLZZFQSMRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  缩水甘油 、 N-乙基苄胺 以 乙醇 为溶剂， 140.0 ℃ 、344.75 kPa 条件下， 反应 0.07h， 以99%的产率得到3-[苄基(乙基)氨基]-1,2-丙烷二醇
  参考文献：
  名称：

  Microwave-Assisted Ring Opening of Epoxides:  A General Route to the Synthesis of 1-Aminopropan-2-ols with Anti Malaria Parasite Activities

  摘要：

  A series of 1-aminopropan-2-ols were synthesized and evaluated against two strains of malaria, Plasmodium falciparum FCR3 (chloroquine-resistant) and 3D7 (chloroquine-sensitive). Microwave-assisted ring opening of epoxides (aryl and alkyl glycidyl ethers, glycidol, epichlorohydrin) with various amines without catalysts generated the desired library of beta-amino alcohols rapidly and efficiently. Most of the compounds showed micromolar potency against malaria, with seven of them having IC50 values between 1 and 10 mu M against both Plasmodium falciparum strains.

  DOI：

  10.1021/jm070553l

文献信息

• ACTIVE RADIATION CURABLE INK COMPOSITION, INK COMPOSITION FOR INKJET RECORDING, PRINTED MATTER, AND METHOD OF PRODUCING MOLDED ARTICLE OF PRINTED MATTER
  申请人：YOKOI Kazuhiro

  公开号：US20110241264A1

  公开（公告）日：2011-10-06

  The present invention provides an active radiation curable ink composition including: (A) a polymer having two or more acidic groups or two or more basic groups; (B) a polymerizable monomer having a substituent group capable of forming a counter salt with the acidic group or basic group of the polymer (A); (C) a photo-polymerization initiator; and (D) a polymerizable monomer having a different structure from the polymerizable monomer (B).
• US8573765B2
  申请人：——

  公开号：US8573765B2

  公开（公告）日：2013-11-05