5-(4-Chlorophenyl)-1-phenylhex-5-en-2-yn-1-one | 1401316-25-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-Chlorophenyl)-1-phenylhex-5-en-2-yn-1-one
• 英文别名: 5-(4-chlorophenyl)-1-phenylhex-5-en-2-yn-1-one
• CAS: 1401316-25-3
• 化学式: C₁₈H₁₃ClO
• 分子量: 280.754
• InChiKey: FEGGTCZUJRWLFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-(4-Chlorophenyl)-1-phenylhex-5-en-2-yn-1-one 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 以78%的产率得到4-chloro-5′-methoxy-1,1′:3′,1″-terphenyl
  参考文献：
  名称：

  Divergent Synthesis of Benzene Derivatives: Brønsted Acid Catalyzed and Iodine-Promoted Tandem Cyclization of 5,2-Enyn-1-ones

  摘要：

  Highly substituted benzene derivatives, including alkoxy-, iodoalkoxy-, and diiodo-substituted benzenes, can be selectively synthesized via Bronsted acid catalyzed and iodine-promoted tandem carbocyclization respectively. This reaction involved a direct process for C C bond formation from 5,2-enyn-1-ones, and different reaction systems (Bronsted acids/electrophiles with solvents) afforded different substituted benzenes. Furthermore, the halogenated moiety and alkoxy group can be readily introduced into the benzene in a position which has not been easily obtained previously.

  DOI：

  10.1021/jo301567p
• 作为产物：
  描述：

  1-(1-溴甲基乙烯基)-4-氯苯 在 manganese(IV) oxide 、 copper(l) iodide 、 四丁基溴化铵 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.25h， 生成 5-(4-Chlorophenyl)-1-phenylhex-5-en-2-yn-1-one
  参考文献：
  名称：

  Divergent Synthesis of Benzene Derivatives: Brønsted Acid Catalyzed and Iodine-Promoted Tandem Cyclization of 5,2-Enyn-1-ones

  摘要：

  Highly substituted benzene derivatives, including alkoxy-, iodoalkoxy-, and diiodo-substituted benzenes, can be selectively synthesized via Bronsted acid catalyzed and iodine-promoted tandem carbocyclization respectively. This reaction involved a direct process for C C bond formation from 5,2-enyn-1-ones, and different reaction systems (Bronsted acids/electrophiles with solvents) afforded different substituted benzenes. Furthermore, the halogenated moiety and alkoxy group can be readily introduced into the benzene in a position which has not been easily obtained previously.

  DOI：

  10.1021/jo301567p

文献信息

• Divergent Synthesis of Benzene Derivatives: Brønsted Acid Catalyzed and Iodine-Promoted Tandem Cyclization of 5,2-Enyn-1-ones
  作者：Fang Yang、Yi-Feng Qiu、Ke-Gong Ji、Yan-Ning Niu、Shaukat Ali、Yong-Min Liang

  DOI：10.1021/jo301567p

  日期：2012.10.19

  Highly substituted benzene derivatives, including alkoxy-, iodoalkoxy-, and diiodo-substituted benzenes, can be selectively synthesized via Bronsted acid catalyzed and iodine-promoted tandem carbocyclization respectively. This reaction involved a direct process for C C bond formation from 5,2-enyn-1-ones, and different reaction systems (Bronsted acids/electrophiles with solvents) afforded different substituted benzenes. Furthermore, the halogenated moiety and alkoxy group can be readily introduced into the benzene in a position which has not been easily obtained previously.