Serine octanoate (ester) | 342046-86-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Serine octanoate (ester)
• 英文别名: (2S)-2-amino-3-octanoyloxypropanoic acid
• CAS: 342046-86-0
• 化学式: C₁₁H₂₁NO₄
• 分子量: 231.29
• InChiKey: QQWGFKGHHSBYPK-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• THERAPEUTIC VITAMIN D CONJUGATES
  申请人：Extend Biosciences, Inc.

  公开号：US20160113993A1

  公开（公告）日：2016-04-28

  The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. In some embodiments, the vitamin D targeting groups are coupled to the apelin proteins via the third carbon on the vitamin D backbone.

  该发明提供了非激素维生素D与apelin蛋白结合形成的产物，与非结合形式相比，其吸收、生物利用度或循环半衰期增加。在某些实施方式中，维生素D的靶向基团通过维生素D骨架上的第三个碳与apelin蛋白偶联。
• Automated identification of peptides
  申请人：——

  公开号：US20020102610A1

  公开（公告）日：2002-08-01

  A fully automated, user-independent method is described for computer-mediated interpretation of data derived by mass spectrometry of an experimental peptide to identify and characterize a corresponding peptide sequence in a peptide database. The method identifies the corresponding sequence if it is present in the database, without the need for a skilled observer to choose from amongst a list of possible matches. By using an automated back-read process, the present method can uniquely identify a corresponding peptide sequence in a database based on a single matching peptide sequence. The method also permits mapping of mass spectral data to sequences in peptide or nucleotide databases for unambiguous identification of exons; determining a correct reading frame; identifying artefacts and errors in sequences; identifying mutations and polymorphisms; identifying post-translational modifications; and identifying exon-intron boundaries.

  本文描述了一种完全自动化、不依赖用户的方法，用于通过质谱技术获得的实验性肽段数据的计算机介导解释，以识别和表征相应的肽段序列在肽段数据库中的对应关系。该方法可以在不需要熟练的观察者从可能匹配的列表中选择的情况下，识别出数据库中存在的相应序列。通过使用自动化的反向读取过程，本方法可以基于单个匹配的肽段序列，在数据库中唯一地识别相应的肽段序列。该方法还允许将质谱数据映射到肽或核苷酸数据库中的序列，以明确识别外显子；确定正确的阅读框架；识别序列中的工件和错误；识别突变和多态性；识别后翻译修饰；以及识别外显子-内含子边界。
• MODIFIED GHERLIN PEPTIDES
  申请人：KANGAWA KENJI

  公开号：US20100240866A1

  公开（公告）日：2010-09-23

  The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种新型肽类化合物，该化合物能够诱导生长激素的分泌并具有增加细胞内钙离子浓度的活性，其中至少有一种氨基酸被修饰的氨基酸和/或非氨基酸化合物替换，或其药学上可接受的盐。
• Detection of peptides
  申请人：Millipore Corporation

  公开号：EP2128619A1

  公开（公告）日：2009-12-02

  A method for determining the presence of one or more proteins of interest in a sample, which method comprises the step of: c) submitting the sample to conditions that allow fragmentation of the protein into target peptide fragments; and d) contacting the target peptide fragments with an array of capture agents immobilized on a solid support, the capture agents comprising those that recognize a target protein fragment; whereby the binding of the target peptide fragments with the capture agents is indicative of the presence of the protein(s) in the sample. A device comprising such an array, and its production, are also described.

  一种确定样品中是否存在一种或多种相关蛋白质的方法，该方法包括以下步骤：c) 将样品置于可将蛋白质破碎成目标肽片段的条件下；d) 将目标肽片段与固定在固体支持物上的捕获剂阵列接触，捕获剂包括可识别目标蛋白质片段的捕获剂；目标肽片段与捕获剂的结合表明样品中存在蛋白质。此外，还介绍了一种包含这种阵列的装置及其生产方法。
• Therapeutic vitamin D conjugates
  申请人：Extend Biosciences, Inc.

  公开号：US10406202B2

  公开（公告）日：2019-09-10

  The invention provides non-hormonal vitamin D conjugated via the third carbon on the vitamin D backbone to parathyroid hormone (PTH) proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms.

  本发明提供了通过维生素 D 骨架上的第三个碳与甲状旁腺激素（PTH）蛋白共轭的非激素类维生素 D，与非共轭形式相比，这种维生素 D 可提高吸收率、生物利用率或循环半衰期。