2-Ethyl-hexanoic acid 2-ethyl-2-hydroxymethyl-hexyl ester | 3964-70-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Ethyl-hexanoic acid 2-ethyl-2-hydroxymethyl-hexyl ester
• 英文别名: Hexanoic acid, 2-ethyl-, 2-ethyl-2-(hydroxymethyl)hexyl ester；[2-ethyl-2-(hydroxymethyl)hexyl] 2-ethylhexanoate
• CAS: 3964-70-3
• 化学式: C₁₇H₃₄O₃
• 分子量: 286.455
• InChiKey: HLIOCTNQCNHHRB-UHFFFAOYSA-N

物化性质

• 沸点：
  344.6±15.0 °C(Predicted)
• 密度：
  0.922±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PERCUTANEOUS PHARMACEUTICAL PREPARATION FOR EXTERNAL USE CONTAINING NONSTEROIDAL ANTIINFLAMMATORY ANALGESIC
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP1752164A1

  公开（公告）日：2007-02-14

  A percutaneous pharmaceutical preparation for external use containing a nonsteroidal antiinflammatory analgesic. It is effective in inhibiting, with higher certainty, the hypersensitivity to light attributable to the phototoxicity and photoallergy of nonsteroidal antiinflammatory analgesics. It can sufficiently produce the effects of the nonsteroidal antiinflammatory analgesic while preventing the pharmaceutical preparation from being altered with time by the incorporation of a dibenzoylmethane derivative as a UVA absorber. The percutaneous pharmaceutical preparation for external use comprises, as essential ingredients, a nonsteroidal antiinflammatory analgesic, a dibenzoylmethane derivative, and one or more members selected among polyhydric alcohol/fatty acid esters, higher fatty acid esters, and crotamiton.

  一种经皮外用药物制剂，含有一种非甾体抗炎镇痛剂。它能更有效地抑制非甾体类消炎镇痛药的光毒性和光过敏性引起的光过敏反应。它既能充分发挥非甾体抗炎镇痛药的功效，又能防止药物制剂因加入二苯甲酰甲烷衍生物作为 UVA 吸收剂而随时间推移发生变化。经皮外用药物制剂的基本成分包括非甾体抗炎镇痛剂、二苯甲酰甲烷衍生物和一种或多种选自多元醇/脂肪酸酯、高级脂肪酸酯和克罗米通的成分。
• COMPOSITION FOR EXTERNAL APPLICATION TO SKIN
  申请人：Rohto Pharmaceutical Co., Ltd.

  公开号：EP2269652A1

  公开（公告）日：2011-01-05

  An object of the present invention is to provide an external composition for skin, which can give good warmth without inducing irritation or pain and whose sustainability of warmth is good enough. The external composition for skin of the present invention is characterized in that it contains (A) an agent for giving warmth and (B) at least one selected from the group consisting of fatty acid esters of aliphatic polyhydric alcohols and aromatic carboxylic acid esters of lower alcohols or aliphatic polyhydric alcohols.

  本发明的目的是提供一种皮肤外用组合物，它能在不引起刺激或疼痛的情况下提供良好的保暖效果，而且保暖效果的持续性足够好。本发明的皮肤外用组合物的特征在于，它含有 (A) 一种保暖剂和 (B) 至少一种选自脂肪族多元醇的脂肪酸酯和低级醇或脂肪族多元醇的芳香族羧酸酯。
• EP1752164B1
  申请人：——

  公开号：EP1752164B1

  公开（公告）日：2014-05-07
• Cosmetic Hair Preparation
  申请人：Satou Nobuyasu

  公开号：US20070275022A1

  公开（公告）日：2007-11-29

  One or more esters selected among an ester of a C 2-10 fatty acid with a polyhydric alcohol, an ester of a monobasic hydroxy acid with a mono- or polyhydric alcohol, and an ester of a polybasic acid with a mono- or polyhydric alcohol are incorporated into a cosmetic hair preparation comprising a crystalline compound and a solvent in which the compound dissolves. Due to this, the crystalline compound is inhibited from crystallizing/precipitating at low temperatures and the preparation can give an improved use feeling during use.
• Percutaneous Pharmaceutical Preparation for External Use Containing Nonsteroidal Antiinflammatory Analgesic
  申请人：Hashimoto Yoshiaki

  公开号：US20070280980A1

  公开（公告）日：2007-12-06

  A percutaneous pharmaceutical preparation for external use containing a nonsteroidal antiinflammatory analgesic. It is effective in inhibiting, with higher certainty, the hypersensitivity to light attributable to the phototoxicity and photoallergy of nonsteroidal antiinflammatory analgesics. It can sufficiently produce the effects of the nonsteroidal antiinflammatory analgesic while preventing the pharmaceutical preparation from being altered with time by the incorporation of a dibenzoylmethane derivative as a UVA absorber. The percutaneous pharmaceutical preparation for external use comprises, as essential ingredients, a nonsteroidal antiinflammatory analgesic, a dibenzoylmethane derivative, and one or more members selected among polyhydric alcohol/fatty acid esters, higher fatty acid esters, and crotamiton.