3-丙基哒嗪 | 28200-53-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 3-丙基哒嗪
• 英文名称: 3-n-Propylpyrazin
• 英文别名: 3-propyl-pyridazine；3-Propyl-pyridazin；3-Propylpyridazine
• CAS: 28200-53-5
• 化学式: C₇H₁₀N₂
• 分子量: 122.17
• InChiKey: DQFWXEPAERVANT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,5-Dimethoxy-2-n-propyl-2,5-dihydrofuran 在 甲醇 、 溶剂黄146 作用下， 生成 3-丙基哒嗪
  参考文献：
  名称：

  Levisalles, Bulletin de la Societe Chimique de France, 1957, p. 1009,1011

  摘要：

  DOI：

文献信息

• COVALENTLY ATTACHED ANTIMICROBIAL POLYMERS
  申请人：Steinberg Thorsten

  公开号：US20130338326A1

  公开（公告）日：2013-12-19

  The present invention relates to substrates comprising covalently attached antimicrobial polymers, which act as synthetic mimics of antimicrobial peptides (SMAMPs) and are preferably obtained by ring opening metathesis polymerization (ROMP). The inventive antimicrobial polymers exhibit a molecular weight of more than 100,000 g mol −1 and are preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. Covalent bonding may be carried out using a photoreactive crosslinker but also by “grafting onto” or “grafting from”. The present invention is also directed to uses of the inventive antimicrobial polymers as defined herein, e.g. for antimicrobially coating a surface of such a substrate with a layer of the inventive antimicrobial polymer.

  本发明涉及包含共价连接的抗菌聚合物的基板，这些聚合物作为抗菌肽（SMAMPs）的合成模拟体，并且最好是通过环烯烃开环甲基交换聚合（ROMP）获得的。这种创新的抗菌聚合物的分子量超过100,000克/摩尔，并且最好是共价连接到基板表面上，例如植入物、医疗器械、医疗设备或（支持组织的）生物材料等。共价键合可以使用光反应性交联剂进行，也可以通过“接枝到”或“接枝自”来进行。本发明还涉及如上所定义的创新抗菌聚合物的用途，例如，用创新抗菌聚合物的层对这种基板的表面进行抗菌涂层。
• SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160031830A1

  公开（公告）日：2016-02-04

  Substituted dihydropyrimidinones of formula 1 which are neutrophil elastase inhibitors and useful as medicaments for the treatment of, inter alia, COPD. Exemplary is

  式1的替代二氢嘧啶酮是中性粒细胞弹性蛋白酶抑制剂，可用作治疗COPD等疾病的药物。
• [EN] 3,4-DIAMINOBENZENESULFONAMIDE DERIVATIVES FOR INHIBITING CELL DEATH<br/>[FR] DÉRIVÉS DE 3,4-DIAMINOBENZÈNESULFONAMIDE POUR INHIBER LA MORT CELLULAIRE
  申请人：VIB VZW

  公开号：WO2016075330A1

  公开（公告）日：2016-05-19

  The present invention relates to a novel class of compounds having the structure of formula (I) and pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof. These compounds inhibit or reduce the non-apoptotic cell death forms ferroptosis and/or oxytosis rendering them useful for the treatment of various conditions disclosed herein.

  本发明涉及一种新型化合物类，其结构式为(I)，以及包含式(I)化合物或其药学上可接受的盐的制药组合物。这些化合物抑制或减少非凋亡细胞死亡形式的铁死亡和/或氧死亡，因此可用于治疗本文所披露的各种疾病。
• IMIDAZOTRIAZINONE COMPOUNDS
  申请人：Ripka Amy

  公开号：US20120157458A1

  公开（公告）日：2012-06-21

  The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

  本发明提供了咪唑三唑酮类化合物，这些化合物是磷酸二酯酶9的抑制剂。本发明还提供了制备这些化合物的方法、药物组成物、制药制剂以及在哺乳动物中（包括人类）治疗与PDE9相关的疾病或紊乱的药物用途。
• SUBSTITUTED DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160031825A1

  公开（公告）日：2016-02-04

  Substituted dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and which are useful as medicaments for the treatment of, inter alia, COPD. Exemplary is

  公式1的替代二氢嘧啶酮，是中性粒细胞弹性蛋白酶活性的抑制剂，可用作治疗COPD等疾病的药物。其中一个例子是：