tert-butyl (7R)-7-(3,4-dichlorophenyl)-6-[2-(6-methoxypyridin-2-yl)-1,2,4-triazol-3-yl]-5-methyl-2-(trifluoromethyl)-7H-pyrazolo[1,5-a]pyrimidine-4-carboxylate | 1431142-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tert-butyl (7R)-7-(3,4-dichlorophenyl)-6-[2-(6-methoxypyridin-2-yl)-1,2,4-triazol-3-yl]-5-methyl-2-(trifluoromethyl)-7H-pyrazolo[1,5-a]pyrimidine-4-carboxylate
• CAS: 1431142-73-2
• 化学式: C₂₇H₂₄Cl₂F₃N₇O₃
• 分子量: 622.434
• InChiKey: GSWQGHIFZOLZSU-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  100
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  tert-butyl (7R)-7-(3,4-dichlorophenyl)-6-[2-(6-methoxypyridin-2-yl)-1,2,4-triazol-3-yl]-5-methyl-2-(trifluoromethyl)-7H-pyrazolo[1,5-a]pyrimidine-4-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 (7R)-7-(3,4-dichlorophenyl)-6-[2-(6-methoxypyridin-2-yl)-1,2,4-triazol-3-yl]-5-methyl-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine
  参考文献：
  名称：

  Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists

  摘要：

  Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of I-Kur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(1) triazole, compound 51, was identified as a potent and selective K(v)1.5 inhibitor with an acceptable PK and liability profile. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.064
• 作为产物：
  描述：

  2-氯-6-甲氧基吡啶 在 一水合肼 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 74.0h， 生成 tert-butyl (7R)-7-(3,4-dichlorophenyl)-6-[2-(6-methoxypyridin-2-yl)-1,2,4-triazol-3-yl]-5-methyl-2-(trifluoromethyl)-7H-pyrazolo[1,5-a]pyrimidine-4-carboxylate
  参考文献：
  名称：

  Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists

  摘要：

  Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of I-Kur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(1) triazole, compound 51, was identified as a potent and selective K(v)1.5 inhibitor with an acceptable PK and liability profile. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.064