2-(Benzylamino)-N-(2-chlorobenzyl)benzamide | 1408002-63-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(Benzylamino)-N-(2-chlorobenzyl)benzamide
• 英文别名: 2-(benzylamino)-N-[(2-chlorophenyl)methyl]benzamide
• CAS: 1408002-63-0
• 化学式: C₂₁H₁₉ClN₂O
• 分子量: 350.848
• InChiKey: XDJVELUNEYTDRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  靛红酸酐 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基乙酰胺 、 二甲基亚砜 为溶剂， 生成 2-(Benzylamino)-N-(2-chlorobenzyl)benzamide
  参考文献：
  名称：

  Novel 2-Aminobenzamides as Potential Orally Active Antithrombotic Agents

  摘要：

  In an effort to develop potent antithrombotic agents, a series of novel 2-aminobenzamide derivatives were synthesized and screened for their in vivo antithrombotic activity. Among the 23 compounds tested, compound (8g) showed the most promising antithrombotic activity, which was comparable with clinically used aspirin or warfarin, but at variance with these standard drugs, 8g did not exhibit the increased bleeding time, suggesting its potential as a novel antithrombotic agent.

  DOI：

  10.1021/ml300217f

文献信息

• Novel 2-Aminobenzamides as Potential Orally Active Antithrombotic Agents
  作者：Amit Verma、Rajani Giridhar、Ashish Kanhed、Anshuman Sinha、Pratik Modh、Mange R. Yadav

  DOI：10.1021/ml300217f

  日期：2013.1.10

  In an effort to develop potent antithrombotic agents, a series of novel 2-aminobenzamide derivatives were synthesized and screened for their in vivo antithrombotic activity. Among the 23 compounds tested, compound (8g) showed the most promising antithrombotic activity, which was comparable with clinically used aspirin or warfarin, but at variance with these standard drugs, 8g did not exhibit the increased bleeding time, suggesting its potential as a novel antithrombotic agent.