2-(4-Ethoxyphenyl)-5-[5-(4-nitrophenyl)furan-2-yl]-1,3,4-oxadiazole | 1410785-79-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Ethoxyphenyl)-5-[5-(4-nitrophenyl)furan-2-yl]-1,3,4-oxadiazole
• 英文别名: 2-(4-ethoxyphenyl)-5-[5-(4-nitrophenyl)furan-2-yl]-1,3,4-oxadiazole
• CAS: 1410785-79-3
• 化学式: C₂₀H₁₅N₃O₅
• 分子量: 377.356
• InChiKey: RIQWEZPHHNFSPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  对乙氧基苯甲酸 在 氯化亚砜 、 硫酸 、 一水合肼 、 三氯氧磷 作用下， 反应 0.17h， 生成 2-(4-Ethoxyphenyl)-5-[5-(4-nitrophenyl)furan-2-yl]-1,3,4-oxadiazole
  参考文献：
  名称：

  Synthesis and Fungicidal Activity of Novel 2,5-Disubstituted-1,3,4-oxadiazole Derivatives

  摘要：

  A novel series of 1,3,4-oxadiazole derivatives containing a 5-phenyl-2-furan moiety were synthesized from the intermediates diacylhydrazine 3 and acylhydrazone 5 via an efficient approach under microwave irradiation in good yields. Their structures were characterized by IR, H-1 NMR, and elemental analysis. The antifungal tests indicated that the title compounds showed in vivo fungicidal activity against Botrytis cinerea and Rhizoctonia solanii at 500 mu g/mL obviously. Some tested compounds even had a superiority effect over the commercial fungicides 40% Pyrimethanil SC and 3% Validamycin AS. The activity between the title compound and their precursors diacylhydrazine 3 and acylhydrazone 5 was also compared and discussed.

  DOI：

  10.1021/jf303807a

文献信息

• Synthesis and Fungicidal Activity of Novel 2,5-Disubstituted-1,3,4-oxadiazole Derivatives
  作者：Zi-Ning Cui、Yan-Xia Shi、Li Zhang、Yun Ling、Bao-Ju Li、Yoshihiro Nishida、Xin-Ling Yang

  DOI：10.1021/jf303807a

  日期：2012.11.28

  A novel series of 1,3,4-oxadiazole derivatives containing a 5-phenyl-2-furan moiety were synthesized from the intermediates diacylhydrazine 3 and acylhydrazone 5 via an efficient approach under microwave irradiation in good yields. Their structures were characterized by IR, H-1 NMR, and elemental analysis. The antifungal tests indicated that the title compounds showed in vivo fungicidal activity against Botrytis cinerea and Rhizoctonia solanii at 500 mu g/mL obviously. Some tested compounds even had a superiority effect over the commercial fungicides 40% Pyrimethanil SC and 3% Validamycin AS. The activity between the title compound and their precursors diacylhydrazine 3 and acylhydrazone 5 was also compared and discussed.