Fmoc (BnO) phospho-homoserine | 1359984-23-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc (BnO) phospho-homoserine
• 英文别名: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[hydroxy(phenylmethoxy)phosphoryl]oxybutanoic acid
• CAS: 1359984-23-8
• 化学式: C₂₆H₂₆NO₈P
• 分子量: 511.468
• InChiKey: WIPMGHWEMHKLBH-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  苯甲醇 在 2,6-二甲基吡啶 、 三氯化磷 作用下， 以 四氢呋喃 为溶剂， 生成 Fmoc (BnO) phospho-homoserine
  参考文献：
  名称：

  A General Preparation of Protected Phosphoamino Acids

  摘要：

  Fmoc-O-benzyk-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was used to prepare a variety of protected phosphoamino acids.

  DOI：

  10.1021/ol203332j

文献信息

• A General Preparation of Protected Phosphoamino Acids
  作者：Daniel E. Petrillo、Dale R. Mowrey、Shawn P. Allwein、Roger P. Bakale

  DOI：10.1021/ol203332j

  日期：2012.3.2

  Fmoc-O-benzyk-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was used to prepare a variety of protected phosphoamino acids.