N-pent-4-enyl-N-phenylbut-3-ynamide | 1403587-50-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-pent-4-enyl-N-phenylbut-3-ynamide
• CAS: 1403587-50-7
• 化学式: C₁₅H₁₇NO
• 分子量: 227.306
• InChiKey: CRWXGDZLTNOJGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-pent-4-enyl-N-phenylbut-3-ynamide 在 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以81%的产率得到2-Pent-4-enyl-2-azatricyclo[5.2.2.01,5]undeca-4,8,10-trien-3-one
  参考文献：
  名称：

  Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts

  摘要：

  The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.

  DOI：

  10.1021/ol302680m
• 作为产物：
  描述：

  N-(pent-4-enyl)aniline 、 3-butynoyl chloride 以 二氯甲烷 为溶剂， 反应 2.0h， 以94%的产率得到N-pent-4-enyl-N-phenylbut-3-ynamide
  参考文献：
  名称：

  Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts

  摘要：

  The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.

  DOI：

  10.1021/ol302680m

文献信息

• Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts
  作者：Jonathan K. Lam、Yvonne Schmidt、Christopher D. Vanderwal

  DOI：10.1021/ol302680m

  日期：2012.11.2

  The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.