Dimethyl 1-(4-chlorophenyl)-4,5-dioxopyrrole-2,3-dicarboxylate | 1360863-99-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: Dimethyl 1-(4-chlorophenyl)-4,5-dioxopyrrole-2,3-dicarboxylate
• 英文别名: dimethyl 1-(4-chlorophenyl)-4,5-dioxopyrrole-2,3-dicarboxylate
• CAS: 1360863-99-5
• 化学式: C₁₄H₁₀ClNO₆
• 分子量: 323.689
• InChiKey: UAIIZSORFYEHGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  90
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-氨基-3-戊烯-2-酮 、 Dimethyl 1-(4-chlorophenyl)-4,5-dioxopyrrole-2,3-dicarboxylate 以 苯 为溶剂， 以84%的产率得到dimethyl 4-acetyl-6-(4-chlorophenyl)-1-hydroxy-3-methyl-7-oxo-2,6-diazabicyclo[3.2.1]oct-3-ene-5,8-dicarboxylate
  参考文献：
  名称：

  [3 + 3]-nucleophilic addition of acyclic enamino ketones to dimethyl 1-aryl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2,3-dicarboxylates

  摘要：

  DOI：

  10.1134/s107042801210020x

文献信息

• Five-membered 2,3-dioxoheterocycles: CVIII. [3+3]-Nucleophilic addition of acyclic enaminoketones to 4,5-dimethoxycarbonyl-1H-pyrrole-2,3-diones. Crystal and molecular structure of substituted 2,6-diazabicyclo[3.2.1]oct-3-enes
  作者：P. S. Silaichev、M. A. Zheleznova、P. A. Slepukhin、A. N. Maslivets

  DOI：10.1134/s1070428014110104

  日期：2014.11

  1-Aryl-4,5-dimethoxycarbonyl-1H-pyrrole-2,3-diones react with 4-aminopent-3-en-2-one and 3-amino-1-phenylbut-2-en-1-one affording dimethyl 4-acyl-1-hydroxy-3-methyl-7-oxo-6-(4-chlorophenyl)-2,6-diazabicyclo[3.2.1]oct-3-ene-5,8-dicarboxylates whose structure was proved by X-ray diffraction analysis.
• Five-membered 2,3-dioxo heterocycles: LXXXII. Recyclization of dimethyl 4,5-Dioxo-4,5-dihydro-1H-pyrrole-2,3-dicarboxylates in reaction with monosubstituted hydrazines. crystalline and molecular structure of dimethyl 1-benzyl-5-(4-methylphenylcarbamoyl)-1H-pyrazole-3,4-dicarboxylate
  作者：P. S. Silaichev、M. A. Chudinova、P. A. Slepukhin、A. N. Maslivets

  DOI：10.1134/s1070428012010174

  日期：2012.1

  Dimethyl 1-aryl(benzyl)-4,5-dioxo-4,5-dihydro-1H-pyrrole-2,3-dicarboxylates reacted with phenylhydrazine and benzylhydrazine to give dimethyl 1-aryl(benzyl)-5-[(aryl or benzyl) carbamoyl]-1H-pyrazole-3,4-dicarboxylates.
• Five-membered 2,3-dioxoheterocycles: XC. Reaction of 4,5-bis(methoxycarbonyl)-1H-pyrrole-2,3-diones with enaminoesters. crystal and molecular structure of 4-methyl 9-ethyl 7-benzyl-3-hydroxy-8-methyl-1-(4-methoxyphenyl)-2,6-dioxo-1,7-diazaspiro[4.4]nona-3,8-diene-4,9-dicarboxylate
  作者：P. S. Silaichev、M. A. Chudinova、P. A. Slepukhin、A. N. Maslivets

  DOI：10.1134/s107042801211005x

  日期：2012.11

  1-Aryl-4,5-bis(methoxycarbonyl)-1H-pyrrole-2,3-diones react with ethyl 3-(benzylamino)but-2-enoate and ethyl 3-(benzylamino)-3-phenylacrylate giving 4-methyl 9-ethyl 1-aryl-7-benzyl-3-hydroxy-8-methyl- and 4-methyl 9-ethyl 1-aryl-7-benzyl-3-hydroxy-8-phenyl-2,6-dioxo-1,7-diazaspiro[4.4]nona-3,8-diene-4,9-dicarboxylates.
• Recyclization of Pyrrolediones with Arylaminoindenones. Synthesis of Indeno[1,2-b]pyridines
  作者：M. V. Dmitriev、P. S. Silaichev、K. V. Lesnikova、M. A. Zheleznova、M. A. Ezhikova、M. I. Kodess、A. N. Maslivets

  DOI：10.1134/s1070428018090154

  日期：2018.9

  Dimethyl 1-aryl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2,3-dicarboxylates reacted with 3-arylamino-1H-inden-1-ones to give the corresponding methyl 1-aryl-3-[2-(arylamino)-2-oxoacetyl]-2,5-dioxo-2,5-dihydro-1H-indeno[1,2-b]pyridine-4-carboxylates.
• [3 + 3]-nucleophilic addition of acyclic enamino ketones to dimethyl 1-aryl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2,3-dicarboxylates
  作者：P. S. Silaichev、M. A. Chudinova、A. N. Maslivets

  DOI：10.1134/s107042801210020x

  日期：2012.10