3-乙氧基硫代苯甲酰胺 | 747411-11-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 3-乙氧基硫代苯甲酰胺
• 中文别名: 3-乙氧基苯-1-硫代羧胺
• 英文名称: 3-ethoxy-thiobenzoic acid amide
• 英文别名: 3-Aethoxy-thiobenzoesaeure-amid；3-Aethoxy-thiobenzamid；3-Ethoxybenzenecarbothioamide
• CAS: 747411-11-6
• 化学式: C₉H₁₁NOS
• mdl: MFCD05270860
• 分子量: 181.258
• InChiKey: LXXDVDKIORLFFH-UHFFFAOYSA-N

物化性质

• 熔点：
  75-77 °C
• 沸点：
  311.9±44.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  67.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  3-乙氧基硫代苯甲酰胺 在 盐酸 、 锌 作用下， 生成 3-乙氧苯基甲胺
  参考文献：
  名称：

  Ethoxybenzyl Ureas

  摘要：

  DOI：

  10.1021/ja01306a048
• 作为产物：
  描述：

  间氨基苯乙醚 在 盐酸 、 乙醇 、 硫化氢 、 氨 、 sodium nitrite 作用下， 生成 3-乙氧基硫代苯甲酰胺
  参考文献：
  名称：

  Ethoxybenzyl Ureas

  摘要：

  DOI：

  10.1021/ja01306a048

文献信息

• Synthesis of Chimeric Thiazolo‐Nootkatone Derivatives as Potent Antimicrobial Agents
  作者：Ibrahim S. Alkhaibari、Hansa Raj K. C.、Rawan Alnufaie、David Gilmore、Mohammad A. Alam

  DOI：10.1002/cmdc.202100230

  日期：2021.9.6

  of fused-thiazole derivatives of nootkatone have been synthesized, and these new compounds were tested against several strains of bacteria. Some of these compounds are found to be potent antimicrobial agents against Staphylococcus aureus and Enterococcus faecium with minimum inhibitory concentration (MIC) values as low as 1.56 μg/mL. The lead compound is bactericidal and very potent against S. aureus

  Nootkatone 是一种经批准的杀虫剂，是一种著名的葡萄柚天然产品。一系列诺卡酮的稠合噻唑衍生物已被合成，并且这些新化合物针对多种细菌菌株进行了测试。其中一些化合物被发现是针对金黄色葡萄球菌和屎肠球菌的有效抗菌剂，最低抑菌浓度 (MIC) 值低至 1.56 μg/mL。该先导化合物具有杀菌作用，并且对金黄色葡萄球菌持续存在非常有效。这些化合物在 10 μm浓度下对人类癌细胞系无毒。
• PROCESS FOR PRODUCING TETRAZOLE COMPOUND AND INTERMEDIATE THEREFOR
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0711762A1

  公开（公告）日：1996-05-15

  There are disclosed an industrially favorable process for producing a tetrazole compound of general formula (1): characterized in that a nitrile of general formula (2):         R¹CN     (2) is reacted with hydrazine or a salt thereof in the presence of a catalyst, followed by reaction with a nitrous acid compound of general formula (3):         ANO₂     (3) or a nitrile of general formula (2) is reacted with hydrogen sulfide, followed by reaction with an alkyl halide of general formula (4):         R⁴J     (4) with hydrazine or a salt thereof, and then with a nitrous acid compound of general formula (3); and an intermediate of general formula (5):         R¹C(=R⁵)R⁶     (5) which is useful for the production of the tetrazole compound (in which R¹ to R⁶, A and J in the above formulas are as defined in the specification).

  本发明公开了一种生产通式（1）四唑化合物的工业化生产工艺： 其特征在于，通式（2）的腈： R¹CN (2) 在催化剂存在下与肼或其盐反应，然后与通式(3)的亚硝酸化合物反应： ANO₂ (3) 或通式（2）的腈与硫化氢反应，然后与通式（4）的烷基卤化物反应： R⁴J (4) 与肼或其盐反应，然后与通式（3）的亚硝酸化合物反应；以及通式（5）的中间体： R¹C(=R⁵)R⁶ (5) 其中上述式中的 R¹ 至 R⁶、A 和 J 如说明书中所定义）。
• Curable polymer latex compositions for the manufacture of rubber articles
  申请人：Synthomer Sdn. Bhd.

  公开号：US11230621B2

  公开（公告）日：2022-01-25

  A curable polymer latex composition obtainable by: (a) subjecting a monomer mixture comprising i. at least one conjugated diene; ii. at least one ethylenically unsaturated nitrile; iii. optionally at least one ethylenically unsaturated acid; iv. optionally at least one further ethylenically unsaturated compound different from any of the compounds (i)-(iii); to free-radical emulsion polymerization in an aqueous reaction medium to form a raw polymer latex; and (b) allowing the obtained raw latex to mature in the presence of at least one thiocarbonyl-functional compound, wherein the at least one thiocarbonyl-functional compound is present in an amount of at least 0.05 wt.-%, based on the total amount of monomers subjected to free-radical emulsion polymerization in step (a), and (c) optionally compounding the matured polymer latex with one or more cross-linking agent. Methods for making such curable polymer latex composition or rubber articles made therefrom, respectively.

  一种可固化聚合物胶乳组合物，可通过以下方法获得 (a) 将包含以下成分的单体混合物 i. 至少一种共轭二烯 至少一种乙烯基不饱和腈； iii； iii. 可选的至少一种乙烯基不饱和酸 iv. 可选的至少一种不同于化合物 (i)-(iii) 的乙烯基不饱和化合物； 在水性反应介质中进行自由基乳液聚合，形成聚合物胶乳原料；和 (b) 使得到的生胶乳在至少一种硫代羰基官能团化合物存在下成熟，其中至少一种硫代羰基官能团化合物的存在量为步骤(a)中进行自由基乳液聚合的单体总量的至少 0.05 wt.-%，和 (c) 可选地将成熟的聚合物胶乳与一种或多种交联剂复合。分别制造这种可固化聚合物胶乳组合物或由其制成的橡胶制品的方法。
• CURABLE POLYMER LATEX COMPOSITIONS FOR THE MANUFACTURE OF RUBBER ARTICLES
  申请人：Synthomer Sdn. Bhd.

  公开号：EP3555198A1

  公开（公告）日：2019-10-23
• Curable Polymer Latex Compositions for the Manufacture of Rubber Articles
  申请人：Synthomer Sdn. Bhd.

  公开号：US20200062879A1

  公开（公告）日：2020-02-27

  A curable polymer latex composition obtainable by: (a) subjecting a monomer mixture comprising i. at least one conjugated diene; ii. at least one ethylenically unsaturated nitrile; iii. optionally at least one ethylenically unsaturated acid; iv. optionally at least one further ethylenically unsaturated compound different from any of the compounds (i)-(iii); to free-radical emulsion polymerization in an aqueous reaction medium to form a raw polymer latex; and (b) allowing the obtained raw latex to mature in the presence of at least one thiocarbonyl-functional compound, wherein the at least one thiocarbonyl-functional compound is present in an amount of at least 0.05 wt.-%, based on the total amount of monomers subjected to free-radical emulsion polymerization in step (a), and (c) optionally compounding the matured polymer latex with one or more cross-linking agent. Methods for making such curable polymer latex composition or rubber articles made therefrom, respectively.