申请人:Olson Matthew W.
公开号:US20100063118A1
公开(公告)日:2010-03-11
The present invention relates to hydantoin derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the hydantoin derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the hydantoin derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.
本发明涉及具有RNase H、聚合酶和/或HIV反转录酶调节活性的咪唑二酮衍生物,特别是具有抑制活性的咪唑二酮衍生物。该发明包括咪唑二酮衍生物、含有该衍生物的组合物、合成该衍生物的方法、筛选识别该衍生物的方法以及使用咪唑二酮衍生物的治疗方法,包括治疗HIV、艾滋病和逆转录病毒相关癌症的方法。